Yang Yanjiang, Wang Xiaorui, Yang Wenwen
Department of Rheumatology and Immunology, The people's Hospital of Qiandongnan Autonomous Prefecture, Kaili, Guizhou Province, China.
School of Pharmacy, Chengdu University, Chengdu, China.
J Asthma. 2025 Mar;62(3):410-415. doi: 10.1080/02770903.2024.2408284. Epub 2024 Oct 1.
Asthma is a common chronic condition with increasing prevalence. Diet, including dried fruit consumption, has been linked to asthma risk, but the mechanisms remain unclear. This study investigates how dried fruit consumption affects asthma risk, focusing on acetate as a potential mediator.
We used Mendelian Randomization (MR) to analyze the relationships between dried fruit intake, acetate levels, and asthma. We applied three MR methods-Inverse-Variance Weighted (IVW), Weighted Median (WM), and MR-Egger-to determine causal effects.
Dried fruit intake was inversely associated with asthma risk (IVW: β = -0.506, = 0.0135) and positively associated with acetate levels (IVW: β = 0.269, < 0.0001). Higher acetate levels were also linked to lower asthma risk (IVW: β=-0.361, < 0.0001). Mediation analysis showed that acetate mediates approximately 19.22% of the effect of dried fruit on asthma risk.
Dried fruit consumption reduces asthma risk, partly through increasing acetate levels. This acetate-mediated pathway accounts for about 20% of the effect, suggesting potential for dietary strategies in asthma prevention and management. Further research could enhance the understanding and applicability of these findings.
哮喘是一种常见的慢性疾病，患病率呈上升趋势。饮食，包括食用干果，与哮喘风险有关，但其机制尚不清楚。本研究调查食用干果如何影响哮喘风险，重点关注乙酸盐作为潜在的中介因素。
我们使用孟德尔随机化（MR）分析干果摄入量、乙酸盐水平和哮喘之间的关系。我们应用了三种MR方法——逆方差加权（IVW）、加权中位数（WM）和MR-Egger——来确定因果效应。
干果摄入量与哮喘风险呈负相关（IVW：β = -0.506，P = 0.0135），与乙酸盐水平呈正相关（IVW：β = 0.269，P < 0.0001）。较高的乙酸盐水平也与较低的哮喘风险相关（IVW：β = -0.361，P < 0.0001）。中介分析表明，乙酸盐介导了干果对哮喘风险影响的约19.22%。
食用干果可降低哮喘风险，部分原因是通过提高乙酸盐水平。这种由乙酸盐介导的途径约占该效应 的20%，表明在哮喘预防和管理中饮食策略具有潜力。进一步的研究可以加深对这些发现的理解和适用性。
