Sharp Rees-Stealy Medical Group.
Ronald Reagan UCLA Medical Center.
Cardiol Clin. 2024 Nov;42(4):521-524. doi: 10.1016/j.ccl.2024.01.009. Epub 2024 Feb 28.
Acute mountain sickness (AMS) commonly plagues people who travel to high altitude and can be life threatening. Clinically, AMS is defined by a constellation of symptoms as outlined in the Lake Louise Criteria. The underlying etiology is thought to be related to a decrease in partial pressure of oxygen leading to tissue hypoxia. Patent foramen ovale (PFO) has been postulated to play a role in AMS through right-to-left shunt, which can worsen hypoxemia. Recent data demonstrate a higher prevalence of PFO in hikers with AMS. Future studies are needed to further elucidate the relationship between PFO and AMS.
急性高原病（AMS）常困扰前往高海拔地区的人群，甚至可能危及生命。临床上，AMS 根据《路易斯湖标准》中概述的一系列症状来定义。其潜在病因被认为与氧气分压下降导致组织缺氧有关。卵圆孔未闭（PFO）通过右向左分流被认为在 AMS 中起作用，从而使低氧血症恶化。最近的数据表明，患有 AMS 的徒步旅行者中 PFO 的患病率更高。需要进一步的研究来阐明 PFO 与 AMS 之间的关系。
