Debray H
Bull Cancer. 1979;66(4):353-72.
After having reviewed the importance of glycoconjugates in the organisation of the cell membrane and the multiple roles played by these membrane constituants, the disorders characteristics of malignant transformation are described : First, the changes affecting cellular properties (diminution of cellular adhesivity, abolition of the control of cell growth, disturbance of membrane permeability...) and second, the modifications concerning the glycoconjugates of the cell surface in the course of malignant transformation : alterations affecting membrane glycolipids and glycoproteins. It appears that certain modifications of glycannic structures of membrane glycoproteins, for whatever cell type and transforming agent, seem at the moment to constitute the only abnormality permanently associated with the tumorigenicity of malignant cells.
在回顾了糖缀合物在细胞膜组织中的重要性以及这些膜成分所发挥的多种作用之后，描述了恶性转化的特征性紊乱：首先是影响细胞特性的变化（细胞黏附性降低、细胞生长控制丧失、膜通透性紊乱……），其次是恶性转化过程中细胞表面糖缀合物的改变：影响膜糖脂和糖蛋白的变化。目前看来，无论细胞类型和转化因子如何，膜糖蛋白聚糖结构的某些改变似乎是与恶性细胞致瘤性永久相关的唯一异常。
