熊去氧胆酸和鹅去氧胆酸对胃蛋白酶活性的抑制作用。
Inhibition of pepsin activity by ursodeoxycholic acids and chenodeoxycholic acids.
作者信息
Eto T, Tompkins R K
出版信息
Am J Surg. 1985 Nov;150(5):564-7. doi: 10.1016/0002-9610(85)90438-6.
PMID:3933371
Abstract
The bile salts of ursodeoxycholic acid, glycoursodeoxycholic acid, tauroursodeoxycholic acid, chenodeoxycholic acid, glycochenodeoxycholic acid, and taurochenodeoxycholic acid were each found to inhibit pepsin proteolytic activity in vitro at various concentrations against the refined substrate n-APDT. The sodium salt of ursodeoxycholic acid was the most potent pepsin inhibitor among those tested.
摘要
熊去氧胆酸、甘氨熊去氧胆酸、牛磺熊去氧胆酸、鹅去氧胆酸、甘氨鹅去氧胆酸和牛磺鹅去氧胆酸的胆盐，在体外针对精制底物n-APDT的各种浓度下均被发现可抑制胃蛋白酶的蛋白水解活性。在测试的这些物质中，熊去氧胆酸钠盐是最有效的胃蛋白酶抑制剂。
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