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台湾地区十年单中心回顾性研究:小儿创伤性脑损伤的急诊手术结果分析。

An Analysis of Emergency Surgical Outcomes for Pediatric Traumatic Brain Injury: A Ten-Year Single-Institute Retrospective Study in Taiwan.

机构信息

Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.

Department of Post-Baccalaureate Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

出版信息

Medicina (Kaunas). 2024 Sep 18;60(9):1518. doi: 10.3390/medicina60091518.

DOI:10.3390/medicina60091518
PMID:39336560
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11434344/
Abstract

: Pediatric traumatic brain injury (pTBI) remains a major pediatric public health problem, despite well-developed injury prevention programs. The purpose of this study is to analyze the emergency surgical outcomes of pTBI in a single institute ten-year retrospective study to offer a real-world clinical result. : Our institute presented a clinical retrospective, single-institute research study of 150 pediatric TBI cases that were diagnosed and underwent emergency surgical treatment from 2010 to 2019. : The incidence of radiological findings is detailed as follows: brain edema (30%, 45/150), followed by acute subdural hematoma (27.3%, 41/150), epidural hematoma (21.3%, 32/150), chronic subdural hemorrhage (10%, 15/150), skull fracture (6.7%, 10/150), and traumatic subarachnoid hemorrhage (4.7%, 7/150). Surgical intervention data revealed that decompressive craniectomy was still the main effective surgical method. The results showed longer hospital stays and higher morbidity rates in the brain edema, acute subdural hematoma, and chronic subdural hemorrhage groups, which were viewed as poor surgical outcome groups. Epidural hematoma, skull fracture and traumatic subarachnoid hemorrhage were categorized into good surgical outcome groups. Notably, the data revealed gross improvement in Glasgow Coma Scale/Score (GCS) evolution after surgical interventions, and the time to cranioplasty was a significant factor in the development of post-traumatic hydrocephalus (PTH). : Our study provided real-world data for the distribution of etiology in pTBI and also categorized it into six groups, indicating disease-orientated treatment. In addition, our data supported that decompressive craniectomy (DC) remains a mainstay surgical treatment in pTBI and early cranioplasty could decrease the incidence of PTH.

摘要

小儿创伤性脑损伤(pTBI)仍然是一个主要的儿科公共卫生问题,尽管有完善的损伤预防计划。本研究的目的是通过单中心十年回顾性研究分析 pTBI 的急诊手术结果,提供真实的临床结果。

我们的研究所进行了一项临床回顾性、单中心研究,纳入了 2010 年至 2019 年期间诊断为 pTBI 并接受急诊手术治疗的 150 例小儿 TBI 病例。

影像学表现的发生率如下

脑水肿(30%,45/150),其次是急性硬膜下血肿(27.3%,41/150)、硬膜外血肿(21.3%,32/150)、慢性硬膜下血肿(10%,15/150)、颅骨骨折(6.7%,10/150)和外伤性蛛网膜下腔出血(4.7%,7/150)。手术干预数据显示,去骨瓣减压术仍然是主要的有效手术方法。结果显示,在脑水肿、急性硬膜下血肿和慢性硬膜下血肿组中,住院时间更长,发病率更高,被视为手术效果不佳组。硬膜外血肿、颅骨骨折和外伤性蛛网膜下腔出血被归类为手术效果良好组。值得注意的是,数据显示手术后格拉斯哥昏迷量表/评分(GCS)的演变有明显改善,并且颅骨成形术的时间是外伤性脑积水(PTH)发展的一个重要因素。

本研究为 pTBI 的病因分布提供了真实世界的数据,并将其分为六组,提示针对病因的治疗。此外,我们的数据支持去骨瓣减压术(DC)仍然是 pTBI 的主要手术治疗方法,早期颅骨成形术可以降低 PTH 的发生率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c0c/11434344/c13aadf807f5/medicina-60-01518-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c0c/11434344/eec159ed8cf6/medicina-60-01518-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c0c/11434344/c13aadf807f5/medicina-60-01518-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c0c/11434344/eec159ed8cf6/medicina-60-01518-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c0c/11434344/c13aadf807f5/medicina-60-01518-g002.jpg

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本文引用的文献

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Pediatric traumatic brain injury prehospital guidelines: a systematic review and appraisal.小儿创伤性脑损伤院前指南:系统评价与评估。
Childs Nerv Syst. 2022 Jan;38(1):51-62. doi: 10.1007/s00381-021-05364-9. Epub 2021 Sep 23.
2
Paediatric chronic subdural haematoma: what are the predisposing factors and outcomes in management of these cases?小儿慢性硬脑膜下血肿:这些病例的处理中,哪些是诱发因素,结果如何?
Childs Nerv Syst. 2022 Jan;38(1):123-132. doi: 10.1007/s00381-021-05341-2. Epub 2021 Sep 6.
3
Posttraumatic Hydrocephalus in Pediatric Patients After Decompressive Craniectomy.
小儿减压性颅骨切除术后的创伤后脑积水
World Neurosurg. 2020 Apr;136:e690-e694. doi: 10.1016/j.wneu.2020.01.153. Epub 2020 Feb 13.
4
Development of Posttraumatic Hydrocephalus Requiring Ventriculoperitoneal Shunt After Decompressive Craniectomy for Traumatic Brain Injury: a Systematic Review and Meta-analysis of Retrospective Studies.创伤性脑损伤减压性颅骨切除术后需行脑室腹腔分流术的创伤后脑积水的发展:一项回顾性研究的系统评价和荟萃分析
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The efficacy and safety of burr-hole craniotomy without continuous drainage for chronic subdural hematoma and subdural hygroma in children under 2 years of age.2岁以下儿童慢性硬膜下血肿和硬膜下积液行钻孔开颅术不持续引流的疗效及安全性
Childs Nerv Syst. 2016 Dec;32(12):2369-2375. doi: 10.1007/s00381-016-3233-9. Epub 2016 Sep 9.
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Trial of Decompressive Craniectomy for Traumatic Intracranial Hypertension.创伤性颅内高压减压性颅骨切除术试验
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7
Epidemiology of Global Pediatric Traumatic Brain Injury: Qualitative Review.全球儿童创伤性脑损伤的流行病学:定性综述
World Neurosurg. 2016 Jul;91:497-509.e1. doi: 10.1016/j.wneu.2016.03.045. Epub 2016 Mar 25.
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Acute care clinical indicators associated with discharge outcomes in children with severe traumatic brain injury.与重度创伤性脑损伤患儿出院结局相关的急性护理临床指标。
Crit Care Med. 2014 Oct;42(10):2258-66. doi: 10.1097/CCM.0000000000000507.
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Early management of severe traumatic brain injury.严重创伤性脑损伤的早期处理。
Lancet. 2012 Sep 22;380(9847):1088-98. doi: 10.1016/S0140-6736(12)60864-2.
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Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents--second edition.婴幼儿、儿童及青少年重度创伤性脑损伤急性医疗管理指南——第二版
Pediatr Crit Care Med. 2012 Jan;13 Suppl 1:S1-82. doi: 10.1097/PCC.0b013e31823f435c.