Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Department of Pharmaceutical, Social and Administrative Sciences, Samford University, Birmingham, AL 35229, USA.
Int J Mol Sci. 2024 Sep 20;25(18):10103. doi: 10.3390/ijms251810103.
Evidence suggests that angiotensin-converting enzyme inhibitors (ACEIs) may increase metabolic rate by promoting thermogenesis, potentially through enhanced fat oxidation and improved insulin. More research is, however, needed to understand this intricate process. In this study, we used 22 lines from the Genetic Reference Panel to assess the metabolic rate of virgin female and male flies that were either fed a standard medium or received lisinopril for one week or five weeks. We demonstrated that lisinopril affects the whole-body metabolic rate in in a genotype-dependent manner. However, the effects of genotypes are highly context-dependent, being influenced by sex and age. Our findings also suggest that lisinopril may increase the metabolic rate via the accumulation of a bradykinin-like peptide, which, in turn, enhances cold tolerance by upregulating and genes. Finally, we showed that knocking down , the ortholog of mammalian ACE in Malpighian/renal tubules and the nervous system, leads to opposite changes in metabolic rate, and that the effect of lisinopril depends on in these systems, but in a sex- and age-specific manner. In conclusion, our results regarding support existing evidence of a connection between ACEI drugs and metabolic rate while offering new insights into this relationship.
证据表明，血管紧张素转换酶抑制剂（ACEI）通过促进产热来提高代谢率，可能是通过增强脂肪氧化和改善胰岛素敏感性来实现的。然而，需要更多的研究来理解这个复杂的过程。在这项研究中，我们使用遗传参考面板中的 22 条系来评估处女雌性和雄性苍蝇在一周或五周内接受标准培养基或赖诺普利喂养时的代谢率。我们表明，赖诺普利以依赖于基因型的方式影响全身代谢率。然而，基因型的影响高度依赖于环境，受到性别和年龄的影响。我们的研究结果还表明，赖诺普利可能通过积累一种类似缓激肽的肽来增加代谢率，从而通过上调 和 基因来增强对冷的耐受性。最后，我们表明，在马氏管/肾小管和神经系统中敲低 ACE 的同源物 ，会导致代谢率发生相反的变化，而赖诺普利的作用取决于这些系统中的 ，但以性别和年龄特异性的方式。总之，我们关于 的结果支持 ACEI 药物与代谢率之间存在联系的现有证据，同时为这种关系提供了新的见解。
