Whitfield Robert, Tipton Craig D, Diaz Niccole, Ancira Jacob, Landry Kyle S
Robert Whitfield MD PLLC, Austin, TX 78746, USA.
RTL Genomics, MicroGen DX, Lubbock, TX 79424, USA.
Microorganisms. 2024 Sep 4;12(9):1830. doi: 10.3390/microorganisms12091830.
The incidence of breast implant illness (BII) and BII-related explant procedures has not decreased with current surgical and treatment techniques. It is speculated the main underlying cause of BII complications is the result of chronic, sub-clinical infections residing on and around the implant. The infection, and subsequent biofilm, produce antagonistic compounds that drive chronic inflammation and immune responses. In this study, the microbial communities in over 600 consecutive samples of infected explant capsules and tissues were identified via next-generation sequencing to identify any commonality between samples. The majority of the bacteria identified were Gram-positive, with and being the dominant organisms. No correlation between sample richness and implant filling was found. However, there was a significant correlation between sample richness and patient age. Due to the complex nature, breast augmentation failures may be better addressed from a holistic approach than one of limited scope.
乳房植入物疾病（BII）及与BII相关的取出植入物手术的发生率，并未因当前的外科手术和治疗技术而降低。据推测，BII并发症的主要潜在原因是植入物表面及周围存在慢性亚临床感染。这种感染以及随后形成的生物膜会产生对抗性化合物，从而引发慢性炎症和免疫反应。在本研究中，通过新一代测序技术对600多个连续的受感染取出植入物包膜和组织样本中的微生物群落进行了鉴定，以确定样本之间的任何共性。鉴定出的大多数细菌为革兰氏阳性菌，其中[具体细菌名称1]和[具体细菌名称2]为优势菌。未发现样本丰富度与植入物填充物之间存在相关性。然而，样本丰富度与患者年龄之间存在显著相关性。由于其复杂性，隆胸失败问题可能采用整体方法比采用范围有限的方法能得到更好的解决。
