Duy Nghia Ngu, Huong Le Thi Thanh, Ravel Patrice, Huong Le Thi Song, Dwivedi Ankit, Kister Guilhem, Gavotte Laurent, Devaux Christian A, Thiem Vu Dinh, Thanh Nguyen Thi Hien, Duong Tran Nhu, Hien Nguyen Tran, Cornillot Emmanuel, Frutos Roger
National Institute of Hygiene and Epidemiology, 1 Yersin Street, Hanoi 100000, Vietnam.
Institut de Recherche en Cancérologie de Montpellier (U1194), IRCM, Université de Montpellier, Campus Val d'Aurelle, CEDEX 5, 34298 Montpellier, France.
Pathogens. 2024 Sep 9;13(9):777. doi: 10.3390/pathogens13090777.
From 2011 to 2012, Northern Vietnam suffered its first large-scale hand, foot, and mouth disease (HFMD) epidemic. Two sets of official guidelines were issued during the outbreak to handle the HFMD crisis. The city of Hai Phong was used as a model to analyze the impact of the released guidelines. A total of 9621 HFMD cases were reported in Hai Phong city from April 2011 to December 2012. Three distinct waves of HFMD occurred. Enterovirus A71 and Coxsackievirus A16 were successively associated with the epidemics. Two periods, before and after the guidelines' release, could be distinguished and characterized by different patient patterns. The time to admission and severity changed notably. Guideline publications help the health system refocus on the 0.5-3 years age group with the highest incidence of the disease. The three waves showed different special distribution, but the main routes of infection were rivers and local secondary roads, most likely through local trade and occupational movements of people.
2011年至2012年，越南北部遭受了首次大规模手足口病疫情。疫情爆发期间发布了两套官方指南以应对手足口病危机。海防市被用作分析所发布指南影响的范例。2011年4月至2012年12月期间，海防市共报告了9621例手足口病病例。手足口病出现了三波明显的疫情。肠道病毒A71和柯萨奇病毒A16先后与这些疫情相关联。可以区分指南发布前后两个时期，并以不同的患者模式为特征。入院时间和病情严重程度发生了显著变化。指南的发布有助于卫生系统重新将重点放在发病率最高的0.5至3岁年龄组。这三波疫情呈现出不同的特殊分布，但主要感染途径是河流和当地二级道路，很可能是通过当地贸易和人员的职业流动。
