Szabó György, Németh Zsolt, Kivovics Márton
Department of Oro-Maxillofacial Surgery and Stomatology, Semmelweis University, Mária Utca 52, Budapest, 1085, Hungary.
Department of Public Dental Health, Semmelweis University, Szentkirályi Utca 40, Budapest, 1088, Hungary.
Maxillofac Plast Reconstr Surg. 2024 Sep 29;46(1):34. doi: 10.1186/s40902-024-00445-6.
Xerostomia, or dry mouth, can be a temporary or persistent symptom resulting from various factors, such as medication use, therapeutic radiation, chemotherapy, autoimmune conditions (e.g., Sjögren's syndrome), and hormonal imbalances. Xerostomia often leads to associated mucositis, which significantly impacts patients' quality of life. The nano-bio-fusion (NBF) gingival gel, a gel-type functional toothpaste containing vitamins C, E, propolis, and herbal extracts in a nano-emulsion state, has shown potential in accelerating the healing of oral mucosal lesions.
A total of 127 patients (102 females, 25 males) with persistent xerostomia were treated from 2018 to 2023. Of these, 32 patients were treated exclusively with NBF Gel, while 95 patients received NBF Gel in combination with other medications, such as pilocarpine. The underlying causes of xerostomia included irradiation and chemotherapy (12 patients), medication (40 patients), hormonal imbalance (28 patients), and Sjögren's syndrome (47 patients). NBF Gel was applied 2-3 times daily to the tongue and oral mucosa. Treatment effectiveness was evaluated through physical examinations and a patient-reported scale ranging from 1 (no improvement) to 10 (complete improvement), focusing on the healing of mucosal lesions rather than saliva production.
Both treatment groups showed significant improvements in the healing of xerostomia-associated mucositis, particularly in severe cases with visible lesions. Patients treated with NBF Gel reported improved symptoms related to mucosal health, while those who received combination therapy also experienced reduced side effects of pilocarpine due to dose reduction. The most substantial improvements were observed in patients with drug-induced and hormonally-caused xerostomia-related mucositis. No adverse side effects from NBF Gel were reported during the study.
NBF gingival gel proved to be beneficial in accelerating the healing of mucositis associated with xerostomia, regardless of the underlying cause, including medication use, radiotherapy, chemotherapy, hormonal imbalances, and Sjögren's syndrome. It presents a promising adjunctive treatment to improve mucosal health and quality of life for patients suffering from xerostomia-associated mucositis.
口干症，即口腔干燥，可能是由多种因素导致的暂时或持续症状，这些因素包括药物使用、放射治疗、化疗、自身免疫性疾病（如干燥综合征）以及激素失衡。口干症常引发相关的口腔黏膜炎，这对患者的生活质量有显著影响。纳米生物融合（NBF）牙龈凝胶是一种凝胶型功能性牙膏，其含有纳米乳液状态的维生素C、维生素E、蜂胶和草药提取物，已显示出在加速口腔黏膜损伤愈合方面的潜力。
2018年至2023年期间，共治疗了127例持续性口干症患者（102例女性，25例男性）。其中，32例患者仅接受NBF凝胶治疗，而95例患者接受NBF凝胶与其他药物（如毛果芸香碱）联合治疗。口干症的潜在病因包括放疗和化疗（12例患者）、药物（40例患者）、激素失衡（28例患者）以及干燥综合征（47例患者）。NBF凝胶每天应用于舌头和口腔黏膜2至3次。通过体格检查和患者报告的从1（无改善）到10（完全改善）的量表来评估治疗效果，重点关注黏膜损伤的愈合而非唾液分泌。
两个治疗组在口干症相关口腔黏膜炎的愈合方面均有显著改善，尤其是在有可见损伤的严重病例中。使用NBF凝胶治疗的患者报告黏膜健康相关症状有所改善，而接受联合治疗的患者由于剂量减少，毛果芸香碱的副作用也有所减轻。在药物性和激素性口干症相关口腔黏膜炎患者中观察到了最显著的改善。研究期间未报告NBF凝胶有不良副作用。
无论潜在病因如何，包括药物使用、放疗、化疗、激素失衡和干燥综合征，NBF牙龈凝胶都被证明有助于加速与口干症相关的口腔黏膜炎的愈合。它为改善患有口干症相关口腔黏膜炎的患者的黏膜健康和生活质量提供了一种有前景的辅助治疗方法。
