Department of Rheumatology and Immunology for Children's Nephropathy, Hainan Women and Children's Medical Center, Haikou, China.
Department of Children's Rehabilitation, Hainan Women and Children's Medical Center, Haikou, China.
PeerJ. 2024 Sep 24;12:e18175. doi: 10.7717/peerj.18175. eCollection 2024.
To investigate the association between the Dietary Inflammatory Index (DII) and disease severity as well as complications in children diagnosed with Henöch-Schönlein purpura (HSP), shedding light on the potential influence of dietary factors on HSP.
A retrospective cohort study was conducted, enrolling children aged 2-14 years diagnosed with HSP. Participants were divided into low and Pro-inflammatory dietary groups based on their DII scores. Biomarkers, nutrient intake, blood lipid profiles and disease complications were compared between the two groups. Spearman correlation analysis was performed to assess the relationship between DII and complications.
A total of 115 patients, including 56 patients with anti-inflammatory dietary and 59 with pro-inflammatory dietary, were included. The pro-inflammatory dietary group demonstrated significantly elevated of C-reactive protein, tumor necrosis factor-α, interleukin-6, erythrocyte sedimentation rate, white blood cell count, eosinophils, IgE, consumption of total calories, protein, carbohydrates, fiber, fat intake, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, VLDL cholesterol, complications of renal, skin, gastrointestinal, coagulation and respiratory in comparison to the anti-inflammatory dietary group. DII was positively correlated with renal, skin, gastrointestinal, coagulation and respiratory complications.
The study highlights the potential influence of dietary inflammatory potential, as quantified by the DII, on disease severity and complications in children with HSP. Understanding the interplay between dietary patterns and inflammatory responses in pediatric vasculitis has implications for the management of HSP, emphasizing the relevance of considering dietary interventions to optimize clinical outcomes and improve the overall well-being of affected children.
探讨膳食炎症指数（DII）与儿童过敏性紫癜（HSP）严重程度和并发症之间的关系，揭示饮食因素对 HSP 的潜在影响。
本研究采用回顾性队列研究，纳入 2-14 岁诊断为 HSP 的儿童。根据 DII 评分，将参与者分为低炎症和促炎症饮食组。比较两组之间的生物标志物、营养素摄入、血脂谱和疾病并发症。采用 Spearman 相关分析评估 DII 与并发症之间的关系。
共纳入 115 例患者，其中抗炎饮食组 56 例，促炎症饮食组 59 例。与抗炎饮食组相比，促炎症饮食组的 C 反应蛋白、肿瘤坏死因子-α、白细胞介素-6、红细胞沉降率、白细胞计数、嗜酸性粒细胞、IgE、总热量、蛋白质、碳水化合物、膳食纤维、脂肪摄入、总胆固醇、LDL 胆固醇、HDL 胆固醇、甘油三酯、VLDL 胆固醇、肾脏、皮肤、胃肠道、凝血和呼吸系统并发症显著升高。DII 与肾脏、皮肤、胃肠道、凝血和呼吸系统并发症呈正相关。
本研究强调了饮食炎症潜力（通过 DII 量化）对 HSP 患儿疾病严重程度和并发症的潜在影响。了解饮食模式与儿科血管炎炎症反应之间的相互作用，对 HSP 的管理具有重要意义，强调考虑饮食干预以优化临床结局并改善受影响儿童的整体健康状况的重要性。
