Cai Bin, Cai Ting, Feng Zeyu, Zhu Huanhuan
Department of Anorectal Surgery, Wuxi Hospital Affiliated to Nanjing University of Chinese Medicine, Wuxi, China.
Department of Nephrology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Wuxi, China.
Front Pharmacol. 2024 Sep 13;15:1404172. doi: 10.3389/fphar.2024.1404172. eCollection 2024.
Cortex Fraxini is a traditional Chinese herb that is widely available, inexpensive, and has low toxicity. Modern pharmacological studies have demonstrated that the active metabolites in Cortex Fraxini, including esculin, esculetin, and fraxetin, exert anti-tumor activities by regulating genes and proteins involved in cancer cell proliferation, apoptosis, invasion, and migration. Additionally, these metabolites play a pivotal role in the regulation of several tumor-associated signaling pathways, including the PI3K/Akt, MAPK/ERK, JAK/STAT3, and Wnt/β-catenin pathways. Due to their pro-apoptotic and anti-proliferative properties and , Cortex Fraxini and its active metabolites may be considered as potential candidates for the treatment of tumor. The aim of this review is to highlight the anti-tumor biological activities and underlying mechanisms of action of the active metabolites of Cortex Fraxini, with a view to providing a reference for their further development and application in the treatment of tumors.
秦皮是一种常见、价格低廉且毒性较低的传统中药。现代药理学研究表明，秦皮中的活性代谢产物，包括七叶苷、七叶亭和秦皮素，通过调节参与癌细胞增殖、凋亡、侵袭和迁移的基因和蛋白质发挥抗肿瘤活性。此外，这些代谢产物在调节几种肿瘤相关信号通路中起关键作用，包括PI3K/Akt、MAPK/ERK、JAK/STAT3和Wnt/β-连环蛋白通路。由于其促凋亡和抗增殖特性，秦皮及其活性代谢产物可被视为肿瘤治疗的潜在候选药物。本综述的目的是强调秦皮活性代谢产物的抗肿瘤生物学活性及其潜在作用机制，以期为其在肿瘤治疗中的进一步开发和应用提供参考。
