铁 TAMs：堕落的守护者。
Iron TAMs: The fallen protectors.
机构信息
Department of Cell Biology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Sydney Kimmel Comprehensive Cancer Center and Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
出版信息
J Exp Med. 2024 Oct 7;221(10). doi: 10.1084/jem.20240951. Epub 2024 Sep 30.
A new study by Folkert et al. (https://doi.org/10.1084/jem.20230420) defines an "iron-rich" subset of tumor-associated macrophages (iTAMs). The metabolism of heme leads to the degradation of the transcriptional repressor Bach1 and shapes the transcriptional profile of iTAMs. The endothelin receptor B in iTAMs signals tumor-supportive functions.
一项由 Folkert 等人开展的新研究（https://doi.org/10.1084/jem.20230420）定义了肿瘤相关巨噬细胞（TAMs）中的“富含铁”亚群。血红素代谢导致转录抑制因子 Bach1 的降解，并塑造 iTAMs 的转录特征。iTAMs 中的内皮素受体 B 信号转导支持肿瘤的功能。
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