University of Michigan Medical School, Ann Arbor, MI, USA.
Brigham and Women's Hospital, Department of Surgery, Harvard Medical School, Boston, MA, USA.
Curr Urol Rep. 2024 Sep 30;26(1):6. doi: 10.1007/s11934-024-01236-2.
The management of noninfectious cystitis continues to evolve as new treatments continue to be developed and investigated. This review aims to synthesize the most recent data regarding management strategies for noninfectious cystitis focused on non-ulcerative, ulcerative, eosinophilic, and ketamine-induced cystitis.
Several novel treatments have shown promise as management options including combination antihistamine therapy, phosphodiesterase 5 inhibitors, alpha lipoic acid supplements, and onabotulinumtoxin A. Recent studies have also found pentosan polysulfate sodium to have adverse ophthalmologic effects. For patients with ulcerative cystitis, recent research has shown that fulguration with or without triamcinolone injections should not be delayed. The treatment of noninfectious cystitis should be patient specific based on factors including etiology and symptom profile. Multimodal regimens are often the most effective. Treatment should be started with conservative options and escalated as necessary to oral treatments, intravesical options, or procedural management.
随着新的治疗方法不断被开发和研究，非感染性膀胱炎的治疗方法也在不断发展。本综述旨在综合最近关于非感染性膀胱炎治疗策略的研究数据，重点关注非溃疡性、溃疡性、嗜酸性粒细胞性和氯胺酮诱导性膀胱炎。
一些新的治疗方法显示出作为治疗选择的潜力，包括联合抗组胺治疗、磷酸二酯酶 5 抑制剂、α-硫辛酸补充剂和肉毒杆菌毒素 A。最近的研究还发现戊聚糖多硫酸钠对眼科有不良影响。对于溃疡性膀胱炎患者，最近的研究表明，电灼联合或不联合曲安奈德注射不应延迟。非感染性膀胱炎的治疗应根据病因和症状特征等因素进行个体化治疗。多模式治疗方案通常最有效。治疗应从保守治疗开始，并根据需要升级为口服治疗、膀胱内治疗或手术治疗。
