Liu Yonghong, Han Jincheng, Hsu Wen-Hao, LaBella Kyle A, Deng Pingna, Shang Xiaoying, Tallón de Lara Paulino, Cai Li, Jiang Shan, DePinho Ronald A
Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Cancer Discov. 2025 Jan 13;15(1):162-178. doi: 10.1158/2159-8290.CD-24-0489.
Clinically available KRAS* inhibitors and IO agents alleviated the immunosuppressive tumor microenvironment in PDAC. Profound tumor regression and prolonged survival in an autochthonous PDAC model provide a compelling rationale for combining KRAS* inhibition with IO agents targeting multiple arms of the immunity cycle to combat PDAC.
临床上可用的KRAS抑制剂和免疫肿瘤(IO)药物缓解了胰腺导管腺癌(PDAC)中的免疫抑制肿瘤微环境。在一个原位PDAC模型中显著的肿瘤消退和生存期延长为将KRAS抑制与针对免疫循环多个环节的IO药物联合起来对抗PDAC提供了令人信服的理论依据。