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Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer.
Nature. 2024 May;629(8013):927-936. doi: 10.1038/s41586-024-07379-z. Epub 2024 Apr 8.
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Design, Synthesis, and Biological Evaluation of Potent and Selective PROTAC Degraders of Oncogenic KRAS.
J Med Chem. 2024 Jan 25;67(2):1147-1167. doi: 10.1021/acs.jmedchem.3c01622. Epub 2024 Jan 10.
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The cancer-immunity cycle: Indication, genotype, and immunotype.
Immunity. 2023 Oct 10;56(10):2188-2205. doi: 10.1016/j.immuni.2023.09.011.
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KRAS inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8 T cells.
Cancer Cell. 2023 Sep 11;41(9):1606-1620.e8. doi: 10.1016/j.ccell.2023.07.002. Epub 2023 Aug 24.
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Pan-KRAS inhibitor disables oncogenic signalling and tumour growth.
Nature. 2023 Jul;619(7968):160-166. doi: 10.1038/s41586-023-06123-3. Epub 2023 May 31.
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Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer.
Nature. 2023 Jun;618(7963):144-150. doi: 10.1038/s41586-023-06063-y. Epub 2023 May 10.
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Adagrasib in Advanced Solid Tumors Harboring a Mutation.
J Clin Oncol. 2023 Sep 1;41(25):4097-4106. doi: 10.1200/JCO.23.00434. Epub 2023 Apr 26.
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Pancreatic cancer: Advances and challenges.
Cell. 2023 Apr 13;186(8):1729-1754. doi: 10.1016/j.cell.2023.02.014.
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Arginase 1 is a key driver of immune suppression in pancreatic cancer.
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