Johnson F L
Am J Pediatr Hematol Oncol. 1985 Fall;7(3):254-7. doi: 10.1097/00043426-198507030-00008.
The possibility of using bone marrow transplantation to treat selected patients with sickle cell anemia has recently been raised by the effectiveness of this approach in an 8-year-old girl suffering from both acute myeloblastic leukemia and sickle cell anemia. The child's sickle cell anemia was converted to the donor's sickle cell trait and she remains in complete remission from her leukemia 22 months following transplantation. This paper considers the therapeutic implications of this child's progress and discusses the major immunological complications, particularly graft-vs.-host disease, which currently limit the more widespread use of marrow transplantation in the therapy of sickle cell anemia.
最近，一名患有急性髓细胞白血病和镰状细胞贫血的8岁女孩通过骨髓移植治疗取得了成效，这引发了使用骨髓移植治疗特定镰状细胞贫血患者的可能性。该患儿的镰状细胞贫血转变为供体的镰状细胞性状，并且在移植后22个月白血病仍处于完全缓解状态。本文探讨了该患儿病情进展的治疗意义，并讨论了目前限制骨髓移植在镰状细胞贫血治疗中更广泛应用的主要免疫并发症，尤其是移植物抗宿主病。
