成人支气管扩张症的患病率：一项荟萃分析。

Prevalence of bronchiectasis in adults: a meta-analysis.

机构信息

Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-Constructed by Henan Province & Education Ministry of P.R. China, Henan University of Chinese Medicine, 156 Jinshui East Road, Zhengzhou, 450046, People's Republic of China.

Henan Key Laboratory of Chinese Medicine for Respiratory Diseases, Henan University of Chinese Medicine, Zhengzhou, 450046, People's Republic of China.

出版信息

BMC Public Health. 2024 Sep 30;24(1):2675. doi: 10.1186/s12889-024-19956-y.

DOI:10.1186/s12889-024-19956-y

PMID:39350110

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11443950/

Abstract

BACKGROUND

Bronchiectasis, once considered an orphan disease, is receiving attention globally owing to its increasing prevalence, healthcare burden, and associated morbidity. However, the prevalence of bronchiectasis is unclear. This meta-analysis estimates the prevalence of bronchiectasis in adults, providing a valuable reference for future research.

METHODS

PubMed, Embase, Cochrane Library, and Web of Science databases were searched from inception to May 31, 2024 for studies reporting the prevalence of bronchiectasis. Study selection, data extraction, and overall analysis of risk of the retrieved studies were conducted independently by two authors. The tool for assessing the risk of bias in prevalence studies was used to evaluate overall risk. Stata software (version 15.1) was used to performed the meta-analysis. Subgroup and sensitivity analyses were conducted to identify the source of heterogeneity. Funnel plots combined with Egger's test were used to detect publication bias.

RESULTS

The pooled prevalence of bronchiectasis in adults from 15 studies covering 437,851,478 individuals was 680 per 100,000 (95% CI: 634-727 per 100,000). Subgroup analysis showed that the prevalence of bronchiectasis in the United States, Korea, and China was 478 per 100,000 (95% CI: 367-588 per 100,000), 886 per 100,000 (95% CI: 778-993 per 100,000), and 759 per 100,000 (95% CI: 35-2399 per 100,000), respectively; 467 per 100,000 (95% CI: 416-518 per 100,000) in males and 535 per 100,000 (95% CI: 477-592 per 100,000) in females; 3958 per 100,000 (95% CI: 117-12637 per 100,000), 4677 per 100,000 (95% CI: 427-8928 per 100,000), and 3630 per 100,000 (95% CI: 158-7103 per 100,000) among never-smokers, ever-smokers, and current smokers, respectively; 430 per 100,000 (95% CI: 411-450 per 100,000), 380 per 100,000 (95% CI: 374-386 per 100,000), and 351 per 100,000 (95% CI: 342-360 per 100,000) among individuals with body mass index<18.5, 18.5-24.9, and ≥ 25, respectively. Sixteen comorbidities were evaluated in patients with bronchiectasis, revealing a high rate.

CONCLUSION

Bronchiectasis is not a rare disease and requires more attention from scientific researchers.

TRIAL REGISTRATION

The protocol for this review was registered with PROSPERO: CRD42023409216. Registered 26 June 2023.

摘要

背景

支气管扩张症曾被认为是一种罕见病，但由于其发病率不断上升、医疗负担加重以及相关发病率较高，目前正受到全球关注。然而，支气管扩张症的发病率尚不清楚。本荟萃分析旨在估计成人支气管扩张症的患病率，为未来的研究提供有价值的参考。

方法

从建库至 2024 年 5 月 31 日，通过 PubMed、Embase、Cochrane 图书馆和 Web of Science 数据库检索报告支气管扩张症患病率的研究。两位作者独立进行研究选择、数据提取和检索研究的总体分析。使用评估患病率研究偏倚的工具来评估总体风险。使用 Stata 软件（版本 15.1）进行荟萃分析。进行亚组和敏感性分析以确定异质性的来源。使用漏斗图结合 Egger 检验来检测发表偏倚。

结果

来自 15 项研究的 437851478 名成年人的数据汇总显示，支气管扩张症的患病率为 680/100000（95%CI：634-727/100000）。亚组分析显示，美国、韩国和中国的支气管扩张症患病率分别为 478/100000（95%CI：367-588/100000）、886/100000（95%CI：778-993/100000）和 759/100000（95%CI：35-2399/100000）；男性患病率为 467/100000（95%CI：416-518/100000），女性患病率为 535/100000（95%CI：477-592/100000）；从不吸烟者、曾经吸烟者和现在吸烟者的患病率分别为 3958/100000（95%CI：117-12637/100000）、4677/100000（95%CI：427-8928/100000）和 3630/100000（95%CI：158-7103/100000）；体重指数<18.5、18.5-24.9 和≥25 的个体的患病率分别为 430/100000（95%CI：411-450/100000）、380/100000（95%CI：374-386/100000）和 351/100000（95%CI：342-360/100000）。在患有支气管扩张症的患者中评估了 16 种合并症，发现其发病率较高。