α-酮酸还原酶的群体研究。

A population study of alpha-keto acid reductase.

作者信息

Friedrich C A, Ferrell R E

出版信息

Ann Hum Genet. 1985 May;49(2):111-4. doi: 10.1111/j.1469-1809.1985.tb01682.x.

DOI:10.1111/j.1469-1809.1985.tb01682.x

Abstract

An electrophoretic survey of 509 individuals of Japanese, Mexican American, American Negro, Eskimo, Amerindian and Anglo-American origin failed to reveal genetically determined variation at the alpha-keto acid reductase locus by starch gel electrophoresis. Additional screening of 232 individuals by thin layer isoelectric focusing in polyacrylamide gels detected a single phenotype. Interspecific variation at the alpha-keto acid reductase locus is clearly resolved using either method. These results indicate that the alpha-keto acid reductase locus is monomorphic in most human population groups despite earlier results suggesting the existence of genetic polymorphism.

摘要

对509名分别来自日本、墨西哥裔美国人、美国黑人、爱斯基摩人、美洲印第安人和英裔美国人的个体进行的电泳调查，未能通过淀粉凝胶电泳揭示α-酮酸还原酶基因座上由遗传决定的变异。通过聚丙烯酰胺凝胶中的薄层等电聚焦对232名个体进行的额外筛查检测到单一表型。使用这两种方法都能清楚地分辨出α-酮酸还原酶基因座的种间变异。这些结果表明，尽管早期结果表明存在遗传多态性，但α-酮酸还原酶基因座在大多数人类群体中是单态的。