Batool Hijab, Khan Madeeha, Ain Quratul, Chughtai Omar R, Khan Muhammad D, Khan Mohammad I, Sadiq Fouzia
Chemical Pathology, Chughtai Institute of Pathology, Lahore, Pakistan.
Directorate of Research, Shifa Tameer-e-Millat University, Pitras Bukhari Road, H-8/4, Islamabad 44000, Pakistan.
Glob Cardiol Sci Pract. 2024 Aug 1;2024(4):e202437. doi: 10.21542/gcsp.2024.37.
Lipoprotein(a) [Lp(a)] is a highly atherogenic particle identified as an independent risk factor for the development of atherosclerotic cardiovascular disease (ASCVD). This study aimed to investigate the frequency of Lp(a) testing and the incidence of elevated Lp(a) levels in the Pakistani population.
For this observational study, Lp(a) and lipid profile data from five years (June 2015 to October 2020) were acquired from the electronic patient records of a diagnostic laboratory with a countrywide network. The association of age and total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), non-HDL, and triglyceride (TG) levels with two thresholds for Lp(a), that is, <30 mg/dL and ≥30 mg/dL, was calculated using the Kruskal-Wallis test, while the association between Lp(a) levels and lipid variables was calculated using Spearman correlation.
For five years, 1060 tests were conducted, averaging 212 tests per year. Of these, 37.2% showed Lp(a) levels above 30 mg/dL. No significant differences were observed in the results between males and females. However, younger individuals displayed significantly higher Lp(a) levels. Additionally, there was only a weak correlation between the Lp(a) levels and other lipid variables.
Despite being recognized as a risk factor for ASCVD in the Pakistani population, only a small proportion of the large population underwent Lp(a) testing. Moreover, a significant proportion of the population exceeded this threshold.
脂蛋白(a) [Lp(a)]是一种高度致动脉粥样硬化的颗粒，被确定为动脉粥样硬化性心血管疾病（ASCVD）发生的独立危险因素。本研究旨在调查巴基斯坦人群中Lp(a)检测的频率以及Lp(a)水平升高的发生率。
在这项观察性研究中，从一个拥有全国性网络的诊断实验室的电子病历中获取了五年（2015年6月至2020年10月）的Lp(a)和血脂谱数据。使用Kruskal-Wallis检验计算年龄与总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、非HDL和甘油三酯（TG）水平与Lp(a)的两个阈值（即<30mg/dL和≥30mg/dL）之间的关联，而使用Spearman相关性计算Lp(a)水平与血脂变量之间的关联。
在五年期间，共进行了1060次检测，平均每年212次。其中，37.2%的检测显示Lp(a)水平高于30mg/dL。男性和女性之间的结果未观察到显著差异。然而，较年轻的个体显示出显著更高的Lp(a)水平。此外，Lp(a)水平与其他血脂变量之间仅存在微弱的相关性。
尽管Lp(a)在巴基斯坦人群中被公认为ASCVD的危险因素，但在大量人群中只有一小部分进行了Lp(a)检测。此外，相当一部分人群超过了这个阈值。
