Department of Diagnostic Radiology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan; Joint Research Laboratory of Advanced Medical Imaging, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Department of Diagnostic Radiology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Magn Reson Imaging. 2024 Dec;114:110240. doi: 10.1016/j.mri.2024.110240. Epub 2024 Sep 29.
The purpose of this study was to determine the capability of proton density with fat fraction (PD-FFQ) imaging to help assess hematopoietic ability and diagnose aplastic anemia in adults.
Between January 2021 and March 2023, patients diagnosed with aplastic anemia (AA: n = 14) or myelodysplastic syndrome (MDS: n = 14) were examined by whole-body PD-FFQ imaging, and 14 of 126 age and gender matched patients who had undergone the same PD-FFQ imaging were selected as control group. All proton density fat fraction (PDFF) index evaluations were then performed by using regions of interest (ROIs). Pearson's correlation was used to determine the relationship between blood test results and each quantitative index, and ROC-based positive test and discrimination analyses to compare capability to differentiate the AA from the non-AA group. Finally, sensitivity, specificity and accuracy of all quantitative indexes were compared by means of McNemar's test.
Mean PDFF, standard deviation (SD) and percentage of coefficient of variation (%CV) for vertebrae showed significant correlation with blood test results (-0.52 ≤ r ≤ -0.34, p < 0.05). Specificity (SP) and accuracy (AC) of %CV of PDFF in vertebrae were significantly higher than those of mean PDFF in vertebrae and the posterior superior iliac spine (SP: p = 0.0002, AC: p = 0.0001) and SD of PDFF in vertebrae (SP: p = 0.008, AC: p = 0.008). Moreover, AC of SD of PDFF in vertebrae was significantly higher than that of mean PDFF in vertebrae and the posterior superior iliac spine (p = 0.03).
Whole-body PD-FFQ imaging is useful for hematopoietic ability assessment and diagnosis of aplastic anemia in adults.
本研究旨在确定质子密度与脂肪分数（PD-FFQ）成像的能力，以帮助评估成人的造血能力和诊断再生障碍性贫血。
2021 年 1 月至 2023 年 3 月，对诊断为再生障碍性贫血（AA：n=14）或骨髓增生异常综合征（MDS：n=14）的患者进行全身 PD-FFQ 成像检查，并选择 14 名与 126 名年龄和性别匹配的接受相同 PD-FFQ 成像检查的患者作为对照组。然后使用感兴趣区域（ROI）对所有质子密度脂肪分数（PDFF）指数评估进行评估。Pearson 相关系数用于确定血液检查结果与每个定量指标之间的关系，并基于 ROC 的阳性测试和鉴别分析比较区分 AA 与非 AA 组的能力。最后，通过 McNemar 检验比较所有定量指标的敏感性、特异性和准确性。
椎体的平均 PDFF、标准差（SD）和变异系数（%CV）与血液检查结果呈显著相关（-0.52≤r≤-0.34，p<0.05）。椎体 PDFF 的 %CV 的特异性（SP）和准确性（AC）明显高于椎体平均 PDFF 和后上髂嵴（SP：p=0.0002，AC：p=0.0001）和椎体 PDFF 的 SD（SP：p=0.008，AC：p=0.008）。此外，椎体 PDFF 的 SD 的 AC 明显高于椎体平均 PDFF 和后上髂嵴（p=0.03）。
全身 PD-FFQ 成像有助于评估成人的造血能力和诊断再生障碍性贫血。
