异质性耐药：抗真菌预防失败背后的隐藏原因。
Heteroresistance: a hidden cause behind antifungal prophylaxis failure.
机构信息
Univ Angers, Univ Brest, IRF, SFR ICAT, F-49000 Angers, France.
Nantes Université, CHU Nantes, Cibles et Médicaments des Infections et de l'Immunité, IICiMed, UR 1155, F-44000 Nantes, France.
出版信息
Trends Microbiol. 2024 Nov;32(11):1042-1044. doi: 10.1016/j.tim.2024.09.008. Epub 2024 Oct 1.
Invasive fungal infections in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients on antimicrobial prophylaxis is a major cause of infectious mortality, although its underlying pathophysiological mechanisms remain unclear. In a new report, Zhai and colleagues provide evidence that heteroresistance drives breakthrough Candida parapsilosis bloodstream infections in allo-HSCT recipients receiving micafungin prophylaxis.
异质性耐药导致接受米卡芬净预防治疗的异基因造血干细胞移植（allo-HSCT）受者发生突破性近平滑念珠菌血流感染，这是侵袭性真菌感染（IFI）导致 allo-HSCT 受者发生感染相关死亡的主要原因之一，但其潜在的病理生理学机制仍不清楚。在一项新的研究中，翟和同事们提供了证据，表明异质性耐药导致接受米卡芬净预防治疗的 allo-HSCT 受者发生突破性近平滑念珠菌血流感染。
Zotero 插件