State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai, P. R. China.
Shanghai Key Laboratory of Sleep Disordered Breathing, Department of Orolaryngology-Head and Neck Surgery, Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China.
Nat Commun. 2024 Oct 1;15(1):8478. doi: 10.1038/s41467-024-52833-1.
Maintaining stillness is essential for accurate bioelectrical signal acquisition, but dynamic noise from breathing remains unavoidable. Isotropic adhesives are often used as bioelectronic interfaces to ensure signal fidelity, but they can leave irreversible residues, compromising device accuracy. We propose a hydrogel with selective frequency damping and asymmetric adhesion as a bioelectronic interface. This hydrogel mitigates dynamic noise from breathing, with a damping effect in the breathing frequency range 60 times greater than at other frequencies. It also exhibits an asymmetric adhesion difference of up to 537 times, preventing residues. By homogenizing ion distribution, extending Debye length, and densifying the electric field, the hydrogel ensures stable signal transmission over 10,000 cycles. Additionally, it can non-invasively diagnose otitis media with higher sensitivity than invasive probes and has been effective in clinical polysomnography monitoring, aiding in the diagnosis of obstructive sleep apnea.
保持静止对于准确获取生物电信号至关重要，但呼吸产生的动态噪声仍然难以避免。各向同性粘合剂通常被用作生物电子接口，以确保信号保真度，但它们可能会留下不可逆转的残留物，从而影响设备的准确性。我们提出了一种具有选择性频率阻尼和不对称附着力的水凝胶作为生物电子接口。这种水凝胶可以减轻呼吸产生的动态噪声，在呼吸频率范围内的阻尼效果比其他频率高出 60 倍。它还表现出高达 537 倍的不对称附着力差异，防止残留物。通过均匀化离子分布、延长德拜长度和密化电场，水凝胶确保了超过 10000 次循环的稳定信号传输。此外，它可以非侵入性地诊断中耳炎，比侵入性探头具有更高的灵敏度，并且在临床多导睡眠图监测中也很有效，有助于诊断阻塞性睡眠呼吸暂停。
