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病例报告：个性化三联噬菌体-抗生素联合疗法救治一名12岁男孩由产杀白细胞素的耐甲氧西林金黄色葡萄球菌引起的坏死性筋膜炎

Case report: Personalized triple phage-antibiotic combination therapy to rescue necrotizing fasciitis caused by Panton-Valentine leukocidin-producing MRSA in a 12-year-old boy.

作者信息

Van Nieuwenhuyse Brieuc, Balcaen Mathilde, Chatzis Olga, Haenecour Astrid, Derycke Emilien, Detaille Thierry, Clément de Cléty Stéphan, Boulanger Cécile, Belkhir Leïla, Yombi Jean-Cyr, De Greef Julien, Cornu Olivier, Docquier Pierre-Louis, Lentini Audrey, Menten Renaud, Rodriguez-Villalobos Hector, Verroken Alexia, Djebara Sarah, Merabishvili Maya, Griselain Johann, Pirnay Jean-Paul, Houtekie Laurent, Van der Linden Dimitri

机构信息

Institute of Experimental and Clinical Research, Pediatric Department (IREC/PEDI), Université catholique de Louvain - UCLouvain, Brussels, Belgium.

Pediatric Intensive Care Unit, Cliniques universitaires Saint-Luc, Université catholique de Louvain - UCLouvain, Brussels, Belgium.

出版信息

Front Cell Infect Microbiol. 2024 Sep 17;14:1354681. doi: 10.3389/fcimb.2024.1354681. eCollection 2024.

DOI:10.3389/fcimb.2024.1354681
PMID:39355265
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11442429/
Abstract

Maximal standard-of-care (SOC) management could not stop the life-threatening progression of a necrotizing fasciitis induced by Panton-Valentine Leukocidin-producing Methicillin-Resistant (MRSA) in a 12-year-old boy. Multi-route phage therapy was initiated along with antibiotics against and , eventually leading to full recovery with no reported adverse events.

摘要

对于一名12岁男孩，最大标准治疗（SOC）管理无法阻止由产生杀白细胞素的耐甲氧西林金黄色葡萄球菌（MRSA）引起的坏死性筋膜炎的危及生命的进展。在使用针对[具体病菌名称1]和[具体病菌名称2]的抗生素的同时开始了多途径噬菌体治疗，最终实现完全康复，且未报告不良事件。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd2/11442429/6a9c6877be73/fcimb-14-1354681-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd2/11442429/ecb4e52a886f/fcimb-14-1354681-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd2/11442429/0e5f827f648e/fcimb-14-1354681-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd2/11442429/6a9c6877be73/fcimb-14-1354681-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd2/11442429/ecb4e52a886f/fcimb-14-1354681-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd2/11442429/0e5f827f648e/fcimb-14-1354681-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd2/11442429/6a9c6877be73/fcimb-14-1354681-g003.jpg

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本文引用的文献

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Genomic Analysis and Outcomes in Patients with Bone and Joint Infections: A Systematic Review.基因组分析及其在骨关节感染患者中的应用：系统综述。
Int J Mol Sci. 2023 Feb 6;24(4):3234. doi: 10.3390/ijms24043234.
2
The 2022 Update of IUIS Phenotypical Classification for Human Inborn Errors of Immunity.2022 年更新的人类先天性免疫缺陷疾病表型分类 IUIS
J Clin Immunol. 2022 Oct;42(7):1508-1520. doi: 10.1007/s10875-022-01352-z. Epub 2022 Oct 6.
3
Case Report: Necrotizing fasciitis caused by positive for a new sequence variant of exfoliative toxin E.
病例报告：由一种新型剥脱毒素E序列变体呈阳性引起的坏死性筋膜炎。
Front Genet. 2022 Sep 15;13:964358. doi: 10.3389/fgene.2022.964358. eCollection 2022.
4
Bacteriophage-antibiotic combination therapy against extensively drug-resistant Pseudomonas aeruginosa infection to allow liver transplantation in a toddler.噬菌体-抗生素联合治疗广泛耐药铜绿假单胞菌感染，以实现婴幼儿肝移植。
Nat Commun. 2022 Sep 29;13(1):5725. doi: 10.1038/s41467-022-33294-w.
5
Panton-Valentine leucocidin-producing Staphylococcus aureus: a clinical review.产 Panton-Valentine 白细胞素的金黄色葡萄球菌：临床综述。
Clin Exp Dermatol. 2022 Dec;47(12):2150-2158. doi: 10.1111/ced.15392. Epub 2022 Oct 11.
6
Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin.人 OTULIN 杂合不足会损害细胞内在对金黄色葡萄球菌α-毒素的免疫。
Science. 2022 Jun 17;376(6599):eabm6380. doi: 10.1126/science.abm6380.
7
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