病例报告：个性化三联噬菌体-抗生素联合疗法救治一名12岁男孩由产杀白细胞素的耐甲氧西林金黄色葡萄球菌引起的坏死性筋膜炎
Case report: Personalized triple phage-antibiotic combination therapy to rescue necrotizing fasciitis caused by Panton-Valentine leukocidin-producing MRSA in a 12-year-old boy.
作者信息
Van Nieuwenhuyse Brieuc, Balcaen Mathilde, Chatzis Olga, Haenecour Astrid, Derycke Emilien, Detaille Thierry, Clément de Cléty Stéphan, Boulanger Cécile, Belkhir Leïla, Yombi Jean-Cyr, De Greef Julien, Cornu Olivier, Docquier Pierre-Louis, Lentini Audrey, Menten Renaud, Rodriguez-Villalobos Hector, Verroken Alexia, Djebara Sarah, Merabishvili Maya, Griselain Johann, Pirnay Jean-Paul, Houtekie Laurent, Van der Linden Dimitri
机构信息
Institute of Experimental and Clinical Research, Pediatric Department (IREC/PEDI), Université catholique de Louvain - UCLouvain, Brussels, Belgium.
Pediatric Intensive Care Unit, Cliniques universitaires Saint-Luc, Université catholique de Louvain - UCLouvain, Brussels, Belgium.
出版信息
Front Cell Infect Microbiol. 2024 Sep 17;14:1354681. doi: 10.3389/fcimb.2024.1354681. eCollection 2024.
Maximal standard-of-care (SOC) management could not stop the life-threatening progression of a necrotizing fasciitis induced by Panton-Valentine Leukocidin-producing Methicillin-Resistant (MRSA) in a 12-year-old boy. Multi-route phage therapy was initiated along with antibiotics against and , eventually leading to full recovery with no reported adverse events.
对于一名12岁男孩，最大标准治疗（SOC）管理无法阻止由产生杀白细胞素的耐甲氧西林金黄色葡萄球菌（MRSA）引起的坏死性筋膜炎的危及生命的进展。在使用针对[具体病菌名称1]和[具体病菌名称2]的抗生素的同时开始了多途径噬菌体治疗，最终实现完全康复，且未报告不良事件。
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