Ruggeri Maria Ludovica, Toto Lisa, D'Aloisio Rossella, Romano Anna, Quarta Alberto, Gironi Matteo, Formenti Federico, Aloia Raffaella, Porreca Annamaria, Di Nicola Marta, Mastropasqua Rodolfo
Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. d'Annunzio Chieti-Pescara, Chieti, Italy.
Laboratory of Biostatistics, Department of Medical, Oral and Biotechnological Sciences, University "G. d'Annunzio" Chieti-Pescara, Chieti, Italy.
Ophthalmologica. 2024;247(5-6):322-330. doi: 10.1159/000540911. Epub 2024 Oct 2.
The aim of this study was to investigate demographic, anatomical, angiographic, and functional parameters in patients suffering from polypoidal choroidal vasculopathy (PCV).
Sixty eyes of 60 patients with a definite diagnosis of treatment-naïve exudative unilateral PCV were evaluated in this retrospective study. Fellow eyes and age-matched healthy subjects were enrolled as comparison. All subjects underwent complete ophthalmic evaluation with multimodal imaging assessment, including spectral-domain optical coherence tomography (OCT) and OCT angiography. Main outcome measures in the comparison analysis were central macular thickness (CMT), subfoveal choroidal thickness (SFCT), and choroidal vascularity index (CVI), whereas outcome measures for correlation analyses were best corrected visual acuity (BCVA), intraretinal fluid and subretinal fluid (SRF) presence, SRF thickness, vascularized pigmented epithelial detachment height, and PCV outer retina to choriocapillaris flow area.
CVI was significantly higher in affected and fellow eyes if compared with the healthy ones (p = 0.049; p = 0.003). Subfoveal choroid resulted to be thicker in the diseased eyes when compared with healthy ones (p = 0.002). A negative correlation was assessed between age and SFCT, CMT, and BCVA. In addition, a significant association between male gender and anatomical and functional parameters has been found with male prevalence at baseline in cases. No association between systemic conditions and PCV features was found.
Patients with unilateral PCV show choroidal changes in terms of higher values of CVI, also in fellow eyes, that were negatively related with age. In our cohort of patients, males showed the poorest diagnosis with a baseline lower BCVA and higher CMT when compared with females. PCV was not associated with any systemic condition.
本研究旨在调查息肉样脉络膜血管病变（PCV）患者的人口统计学、解剖学、血管造影和功能参数。
本回顾性研究评估了60例确诊为未经治疗的单侧渗出性PCV患者的60只眼。纳入对侧眼和年龄匹配的健康受试者作为对照。所有受试者均接受了包括光谱域光学相干断层扫描（OCT）和OCT血管造影在内的多模态成像评估的完整眼科检查。比较分析的主要观察指标为中心黄斑厚度（CMT）、黄斑中心下脉络膜厚度（SFCT）和脉络膜血管指数（CVI），而相关性分析的观察指标为最佳矫正视力（BCVA）、视网膜内液和视网膜下液（SRF）的存在情况、SRF厚度、血管化色素上皮脱离高度以及PCV外视网膜至脉络膜毛细血管血流面积。
与健康受试者相比，患眼和对侧眼的CVI显著更高（p = 0.049；p = 0.003）。与健康受试者相比，患病眼的黄斑中心下脉络膜更厚（p = 0.002）。年龄与SFCT、CMT和BCVA之间存在负相关。此外，发现男性性别与解剖学和功能参数之间存在显著关联，病例基线时男性患病率较高。未发现全身状况与PCV特征之间存在关联。
单侧PCV患者的患眼以及对侧眼均表现出脉络膜变化，表现为CVI值较高，且与年龄呈负相关。在我们的患者队列中，与女性相比，男性的诊断最差，基线时BCVA较低，CMT较高。PCV与任何全身状况均无关联。
