Chang Jinjie, Zhang Ying, Li Jun, He Chunlin, Pang Siping
Laboratory of Drug Discovery and Design, School of Pharmaceutical Sciences and Food Engineering, Liaocheng University, Liaocheng 252000, Shandong, China.
School of Materials Science & Engineering, Beijing Institute of Technology, Beijing 100081, China.
ACS Appl Mater Interfaces. 2024 Oct 16;16(41):55578-55589. doi: 10.1021/acsami.4c14222. Epub 2024 Oct 3.
Biosafety is crucial to the common interests of all humanity. Currently, global biosafety governance is a challenge and poses significant opportunities. With the escalating challenges posed by microorganisms, there is an urgent need to develop advanced biocidal materials. In this work, we introduce a class of iodine-containing high-energy biocidal materials, utilizing pyrazine rings with good thermal stability as nitrogen-rich high-energy backbones, to address the issues of corrosion and hygroscopicity associated with N-H acidic protons in traditional iodine-containing azole compounds. Employing nucleophilic substitution and coupling reactions, we successfully synthesized two distinct series of eight compounds (Series A: BQDI, BQFI, BQDIO; Series B: BBQ3I, BBQ4I, BBQNI, MBQ5I, and MBQDI), which exhibit a high iodine content and enhanced detonation pressure. Notably, compounds BQDIO and BBQNI show detonation pressures of 13.70 and 16.52 GPa, respectively, both exceeding the 10 GPa of traditional iodine-containing biocidal materials. This improvement is crucial for expanding the diffusion range of biocidal substances and enhancing the biocidal efficiency of these materials. Pyrazine-based iodine-containing compounds have revolutionized the performance of biocidal materials, addressing corrosion issues and paving the way for the development of efficient, stable, and safe biocidal materials.
生物安全对全人类的共同利益至关重要。当前，全球生物安全治理既是挑战，也带来了重大机遇。随着微生物带来的挑战不断升级，迫切需要研发先进的杀菌材料。在这项工作中，我们引入了一类含碘高能杀菌材料，利用具有良好热稳定性的吡嗪环作为富氮高能主链，以解决传统含碘唑类化合物中与N-H酸性质子相关的腐蚀和吸湿性问题。通过亲核取代和偶联反应，我们成功合成了两个不同系列的八种化合物（系列A：BQDI、BQFI、BQDIO；系列B：BBQ3I、BBQ4I、BBQNI、MBQ5I和MBQDI），这些化合物具有高碘含量和增强的爆轰压力。值得注意的是，化合物BQDIO和BBQNI的爆轰压力分别为13.70 GPa和16.52 GPa，均超过了传统含碘杀菌材料的10 GPa。这一改进对于扩大杀菌物质的扩散范围和提高这些材料的杀菌效率至关重要。基于吡嗪的含碘化合物彻底改变了杀菌材料的性能，解决了腐蚀问题，为高效、稳定和安全的杀菌材料的开发铺平了道路。
