School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo 255000, PR China.
School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255000, PR China.
Food Chem. 2025 Jan 15;463(Pt 4):141458. doi: 10.1016/j.foodchem.2024.141458. Epub 2024 Sep 27.
Viscosity is closely associated with physiological and pathological processes, as well as food quality. Herein, a novel fluorescent molecular rotor, BMCY-V, was presented and applied for detection of viscosity. BMCY-V contained a benzoindole unit as electron donor and a malononitrile group as acceptor. In low-viscous solvents, the rotor can freely rotate, leading to dissipation of excited-state energy. In high-viscous media, however, the free rotation of the rotor is severely restricted, thus reducing non-radiative transition and resulting in significantly enhanced fluorescence intensity. BMCY-V is extremely sensitive to viscosity, showing about 3968 times increase of fluorescence intensity at 728 nm from water to 95 % glycerol. Due to the excellent photophysical property such as near-infrared emission, BMCY-V was successfully used to visualize viscosity in live cells and in liver tissues. In addition, BMCY-V can also evaluate the thickening effect of various thickeners and visualize the changes of viscosity during deterioration of fluid drinks.
粘度与生理和病理过程以及食品质量密切相关。在此，我们提出了一种新型荧光分子转子 BMCY-V，并将其用于粘度检测。BMCY-V 含有苯并吲哚单元作为电子给体和丙二腈基团作为受体。在低粘度溶剂中，转子可以自由旋转，导致激发态能量耗散。然而，在高粘性介质中，转子的自由旋转受到严重限制，从而减少了非辐射跃迁，导致荧光强度显著增强。BMCY-V 对粘度极其敏感，在从水到 95%甘油的过程中，728nm 处的荧光强度增加了约 3968 倍。由于具有近红外发射等优异的光物理性质，BMCY-V 成功地用于活细胞和肝组织中的粘度可视化。此外，BMCY-V 还可以评估各种增稠剂的增稠效果，并可视化流体饮料劣化过程中粘度的变化。
