Department of Oncology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Lung Cancer Institute, Jinan, China.
Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Front Immunol. 2024 Sep 19;15:1408474. doi: 10.3389/fimmu.2024.1408474. eCollection 2024.
Chinese Herbal Medicine (CHM) is being more and more used in cancer treatment because of its ability to regulate the immune system. Chinese Herbal Medicine has several advantages over other treatment options, including being multi-component, multi-target, and having fewer side effects. Dendritic cells (DCs) are specialized antigen presenting cells that play a vital part in connecting the innate and adaptive immune systems. They are also important in immunotherapy. Recent evidence suggests that Chinese Herbal Medicine and its components can positively impact the immune response by targeting key functions of dendritic cells. In this review, we have summarized the influences of Chinese Herbal Medicine on the immunobiological feature of dendritic cells, emphasized an anti-tumor effect of CHM-treated DCs, and also pointed out deficiencies in the regulation of DC function by Chinese Herbal Medicine and outlined future research directions.
中草药（CHM）因其调节免疫系统的能力而在癌症治疗中越来越多地被使用。与其他治疗选择相比，中草药具有几个优势，包括多成分、多靶点和副作用较少。树突状细胞（DCs）是专门的抗原呈递细胞，在连接先天和适应性免疫系统方面起着至关重要的作用。它们在免疫疗法中也很重要。最近的证据表明，中草药及其成分可以通过针对树突状细胞的关键功能来积极影响免疫反应。在这篇综述中，我们总结了中草药对树突状细胞免疫生物学特征的影响，强调了 CHM 处理的 DCs 的抗肿瘤作用，还指出了中草药调节 DC 功能的缺陷，并概述了未来的研究方向。
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