State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Life Sciences, Xiamen University, Xiamen 361102, China; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, National Innovation Platform for Industry-Education Integration in Vaccine Research, NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, Xiamen University, Xiamen 361102, China.
State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Life Sciences, Xiamen University, Xiamen 361102, China; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, National Innovation Platform for Industry-Education Integration in Vaccine Research, NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, Xiamen University, Xiamen 361102, China.
Structure. 2024 Nov 7;32(11):1877-1892. doi: 10.1016/j.str.2024.09.011. Epub 2024 Oct 4.
Human papillomavirus (HPV), known for its oncogenic properties, is the primary cause of cervical cancer and significantly contributes to mortality rates. It also plays a considerable role in the globally rising incidences of head and neck cancers. These cancers pose a substantial health burden worldwide. Current limitations in diagnostic and treatment strategies, along with inadequate coverage of preventive vaccines in low- and middle-income countries, hinder the progress toward the World Health Organization (WHO) HPV prevention and control targets set for 2030. In response to these challenges, extensive research in structural virology has explored the properties of HPV proteins, yielding crucial insights into the mechanisms of HPV infection that are important for the development of prevention and therapeutic strategies. This review highlights recent advances in understanding the structures of HPV proteins and discusses achievements and future opportunities for HPV vaccine development.
人乳头瘤病毒（HPV），以其致癌特性而闻名，是宫颈癌的主要病因，也是导致死亡率升高的重要因素。它还在全球范围内头颈部癌症发病率的上升中扮演了重要角色。这些癌症给全球健康带来了沉重的负担。目前在诊断和治疗策略方面存在局限性，以及在中低收入国家中预防性疫苗的覆盖不足，阻碍了实现世界卫生组织（WHO）为 2030 年设定的 HPV 预防和控制目标的进展。针对这些挑战，结构病毒学的广泛研究探索了 HPV 蛋白的特性，为 HPV 感染机制提供了重要的见解，这些机制对于开发预防和治疗策略至关重要。本综述重点介绍了对 HPV 蛋白结构的理解的最新进展，并讨论了 HPV 疫苗开发的成就和未来机遇。
