School of Medicine, Nankai University, Tianjin, China.
Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Tianjin Eye Hospital, Nankai University Affiliated Eye Hospital, Tianjin, China.
Sci Rep. 2024 Oct 5;14(1):23187. doi: 10.1038/s41598-024-74497-z.
Keratoconus (KC) is an irreversible blinding eye disease; therefore, early screening of KC suspects (KCS) is crucial for protecting patients' quality of life. Scheimpflug imaging is a commonly used screening device in clinical practice. We aimed to evaluate the diagnostic ability of a Scheimpflug imaging device (Scansys) for KC and KCS and compared it with other Scheimpflug-based devices (Pentacam and Corvis ST). This prospective case-control study included 107 normal eyes, 72 KCS, and 57 KC. Scansys screening index Keratoconus probability (KCP) showed excellent performance in diagnosing KC at a cutoff value of 16.4 (area under the receiver operating characteristic [AUROC] = 1.000), with 100% sensitivity and 98.11% specificity. KCP had a better KCS diagnostic ability at a cutoff value of 8.9 (AUROC = 0.813) than Corvis biomechanical index (CBI, AUROC = 0.764), reaching 67.61% sensitivity and 85.85% specificity. Pentacam screening index Belin/Ambrósio enhanced ectasia display deviation (BAD-D) showed the best performance with 92.96% sensitivity and 89.62% specificity at a cutoff value of 1.525 (AUROC = 0.970) in diagnosing KCS. Scansys provides accurate KCP parameters in diagnosing KC; however, the efficiency of diagnosing KCS should be further optimized.
圆锥角膜（KC）是一种不可逆转的致盲眼病；因此，对 KC 疑似患者（KCS）进行早期筛查对于保护患者的生活质量至关重要。Scheimpflug 成像仪是临床实践中常用的筛查设备。我们旨在评估 Scheimpflug 成像仪（Scansys）对 KC 和 KCS 的诊断能力，并将其与其他基于 Scheimpflug 的设备（Pentacam 和 Corvis ST）进行比较。这项前瞻性病例对照研究包括 107 只正常眼、72 只 KCS 和 57 只 KC。Scansys 筛查指数圆锥角膜概率（KCP）在截断值为 16.4 时（AUROC=1.000）对诊断 KC 具有出色的性能，敏感性为 100%，特异性为 98.11%。在截断值为 8.9 时，KCP 对 KCS 的诊断能力优于 Corvis 生物力学指数（CBI，AUROC=0.764），达到 67.61%的敏感性和 85.85%的特异性。Pentacam 筛查指数 Belin/Ambrósio 增强扩张显示偏差（BAD-D）在截断值为 1.525 时（AUROC=0.970）表现出最佳性能，对 KCS 的诊断具有 92.96%的敏感性和 89.62%的特异性。Scansys 在诊断 KC 时提供了准确的 KCP 参数；然而，诊断 KCS 的效率应进一步优化。
