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晚期早产出生的婴儿:住院分娩期间的管理

Infants Born at Late Preterm Gestation: Management during the Birth Hospitalization.

作者信息

Joshi Neha S, Profit Jochen, Frymoyer Adam, Flaherman Valerie J, Gu Yuan, Lee Henry C

机构信息

Department of Pediatrics, Stanford University, Stanford, CA.

Department of Pediatrics, Stanford University, Stanford, CA.

出版信息

J Pediatr. 2025 Jan;276:114330. doi: 10.1016/j.jpeds.2024.114330. Epub 2024 Oct 5.

Abstract

OBJECTIVE

To examine the admission practices, frequency of common clinical morbidities, and rates of medical intervention in infants born at 34-36 weeks gestational age (GA, late preterm).

STUDY DESIGN

This retrospective, single institution, cohort study analyzed electronic health records of infants born late preterm from 2019 through 2021. Infants with known congenital anomalies necessitating neonatal intensive care unit admission were excluded. Analysis included descriptive and inferential statistics.

RESULTS

The study included 1022 infants: 209 (21%) 34 weeks GA, 263 (26%) 35 weeks GA, and 550 (54%) 36 weeks GA. Sixty-three percent of infants at 35 weeks GA and 78% of infants of 36 weeks GA remained in well newborn care throughout the birth hospitalization; infants born at 34 weeks GA were ineligible for well newborn care. The need for respiratory support was 32%, 18%, and 11% in infants of 34, 35, and 36 weeks GA, respectively. Supplemental tube feeds were administered in 55%, 24%, and 8% of infants of 34, 35, and 36 weeks GA, respectively. Most infants born at 34 weeks GA (91%) were placed in an incubator; this was less frequent in infants at 35 (37%) and 36 weeks (16%). Tachypnea, hypoglycemia, and hypothermia were noted in 40%, 61%, and 57% of infants, respectively. A subset of these infants (30% with tachypnea, 23% with hypoglycemia, and 46% with hypothermia) required medical intervention for these abnormalities.

CONCLUSIONS

This single-center study provides an outlook on the care of infants born late preterm. Multicenter studies can contextualize these findings in order to develop clinical benchmarks and quality markers for this large population of infants.

摘要

目的

研究孕34 - 36周(孕晚期早产)出生婴儿的入院情况、常见临床疾病的发生频率以及医疗干预率。

研究设计

这项回顾性、单机构队列研究分析了2019年至2021年晚期早产婴儿的电子健康记录。排除已知患有先天性异常且需要入住新生儿重症监护病房的婴儿。分析包括描述性和推断性统计。

结果

该研究纳入了1022名婴儿:209名(21%)孕34周,263名(26%)孕35周,550名(54%)孕36周。孕35周的婴儿中有63%以及孕36周的婴儿中有78%在整个出生住院期间都接受正常新生儿护理;孕34周出生的婴儿不符合正常新生儿护理条件。孕34、35和36周的婴儿中,需要呼吸支持的比例分别为32%、18%和11%。孕34、35和36周的婴儿中,分别有55%、24%和8%接受了补充管饲喂养。大多数孕34周出生的婴儿(91%)被放入暖箱;孕35周(37%)和36周(16%)的婴儿中这一情况较少见。分别有40%、61%和57%的婴儿出现呼吸急促、低血糖和体温过低。这些婴儿中的一部分(呼吸急促的占30%,低血糖的占23%,体温过低的占46%)因这些异常情况需要医疗干预。

结论

这项单中心研究提供了关于晚期早产婴儿护理的情况。多中心研究可以将这些发现置于具体情境中,以便为这一大量婴儿群体制定临床基准和质量指标。

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