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Trophoblastic disease and choriocarcinoma.

作者信息

Camilleri Graziella, Calleja-Aguis Jean, Said Edith

机构信息

Department of Anatomy, Faculty of Medicine and Surgery University of Malta, Malta; Department of Pathology, Mater Dei Hospital, Malta.

Department of Anatomy, Faculty of Medicine and Surgery University of Malta, Malta.

出版信息

Eur J Surg Oncol. 2025 Apr;51(4):108727. doi: 10.1016/j.ejso.2024.108727. Epub 2024 Oct 1.

DOI:10.1016/j.ejso.2024.108727
PMID:39370364
Abstract

Gestational trophoblastic disease (GTD) is a group of diseases associated with pregnancies that demonstrate abnormal development of trophoblastic cells. GTD includes hydatidiform moles (HM) that may continue to further develop into gestational trophoblastic neoplasms (GTN), such as choriocarcinoma (CC). Gestational CC is a malignant mass development that may arise from HM, from other (normal) pregnancies or from other gestational events (such as ectopic pregnancies). The aim of this review is to outline current understating of the genetics and epigenetics of GTD and gestational CC and the link between the two diseases.

摘要

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