Zou Xiongfei, Xu Hongjun, Qian Wenwei
Department of Orthopedic Surgery, Peking Union Medical College Hospital, Beijing, China.
Drug Metab Rev. 2024 Nov;56(4):399-412. doi: 10.1080/03602532.2024.2402751. Epub 2024 Oct 8.
Osteoarthritis (OA) is a chronic degenerative disease caused by various factors such as aging, obesity, trauma, and genetics. It is a challenging condition faced by orthopedic doctors in clinical practice and places a heavy burden on patients and their families. Currently, the treatment of OA primarily focuses on symptomatic relief and lacks ideal therapeutic methods. Resveratrol is a natural polyphenolic compound with anti-inflammatory and antioxidant properties, and in recent years, it has gained attention as a candidate drug for OA treatment. This article provides an overview of the research status on the role and mechanisms of resveratrol in treating OA. It has been found that resveratrol can prevent the development of OA by inhibiting inflammatory responses, protecting chondrocytes, maintaining cartilage homeostasis, promoting autophagy, and has shown certain therapeutic effects. This process may be related to the regulation of signaling pathways such as nuclear factor-kappa B (NF-κB), Toll-like receptor 4 (TLR4), and silent information regulator 1 (SIRT1). We summarize the current molecular mechanisms of resveratrol in treating OA, hoping to provide a reference for further research and application of resveratrol in OA treatment.
骨关节炎（OA）是一种由衰老、肥胖、创伤和遗传等多种因素引起的慢性退行性疾病。它是骨科医生在临床实践中面临的具有挑战性的病症，给患者及其家庭带来沉重负担。目前，OA的治疗主要集中在症状缓解，缺乏理想的治疗方法。白藜芦醇是一种具有抗炎和抗氧化特性的天然多酚化合物，近年来，它作为OA治疗的候选药物受到关注。本文综述了白藜芦醇在治疗OA中的作用及机制的研究现状。研究发现，白藜芦醇可通过抑制炎症反应、保护软骨细胞、维持软骨稳态、促进自噬来预防OA的发展，并已显示出一定的治疗效果。这一过程可能与核因子-κB（NF-κB）、Toll样受体4（TLR4）和沉默信息调节因子1（SIRT1）等信号通路的调节有关。我们总结了白藜芦醇治疗OA的当前分子机制，希望为白藜芦醇在OA治疗中的进一步研究和应用提供参考。
