重症恶性疟的潜在危害：青蒿琥酯治疗后迟发性溶血。

The sting in the tail of severe falciparum malaria: Post-artesunate delayed haemolysis.

作者信息

Benjamin Yael, Stead David

机构信息

Department of Internal Medicine, Frere Hospital, East London, South Africa.

Department of Medicine, Faculty of Health Sciences, Walter Sisulu University, Mthatha, South Africa.

出版信息

S Afr J Infect Dis. 2022 May 25;37(1):392. doi: 10.4102/sajid.v37i1.392. eCollection 2022.

DOI:10.4102/sajid.v37i1.392

PMID:39376532

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11457264/

Abstract

Post-artesunate delayed haemolysis (PADH) is thought to occur because of delayed clearance of previously malarial infected erythrocytes spared by 'pitting' during treatment. We report a case of PADH following the treatment of malaria (32% parasitaemia), with a positive direct antiglobulin (DAT) test, suggesting an immune mechanism.

摘要

青蒿琥酯治疗后延迟性溶血（PADH）被认为是由于治疗期间通过“凹陷”得以保留的先前感染疟原虫的红细胞清除延迟所致。我们报告了一例疟疾（寄生虫血症32%）治疗后发生PADH的病例，其直接抗球蛋白试验（DAT）呈阳性，提示存在免疫机制。