大鼠奋乃静诱导的紧张症中γ-氨基丁酸能、多巴胺能和胆碱能的相互作用

GABAergic, dopaminergic and cholinergic interactions in perphenazine-induced catatonia in rats.

作者信息

Shukla V K, Garg S K, Mathur V S, Kulkarni S K

出版信息

Arch Int Pharmacodyn Ther. 1985 Dec;278(2):236-48.

Abstract

Anticatatonic effects of systemic and intracerebroventricularly administered GABAergic agents (GABA, muscimol piracetam, sod. valproate) were studied in rats against perphenazine-induced catatonia. All GABAergic agents, except piracetam, were found to posses anticatatonic actions as they significantly blocked perphenazine-induced catatonia. When these GABAergic agents were administered simultaneously with anticholinergic (scopolamine) or dopaminergic (bromocriptine) substances there was potentiation of the anticatatonic effect. The protective effect of GABAergic agonists and GABA antagonist and its modification by anticholinergic and dopaminergic agents has been explained on the basis of neurotransmitter interaction.

摘要

研究了全身性和脑室内注射的γ-氨基丁酸能药物（γ-氨基丁酸、蝇蕈醇、吡拉西坦、丙戊酸钠）对大鼠奋乃静诱导的紧张症的抗紧张症作用。发现除吡拉西坦外，所有γ-氨基丁酸能药物都具有抗紧张症作用，因为它们能显著阻断奋乃静诱导的紧张症。当这些γ-氨基丁酸能药物与抗胆碱能药物（东莨菪碱）或多巴胺能药物（溴隐亭）同时给药时，抗紧张症作用增强。基于神经递质相互作用，对γ-氨基丁酸能激动剂和拮抗剂的保护作用及其被抗胆碱能和多巴胺能药物的修饰进行了解释。