College of Chemical Engineering, Changchun University of Technology, Changchun 130012, PR China.
College of Chemical Engineering, Changchun University of Technology, Changchun 130012, PR China.
Spectrochim Acta A Mol Biomol Spectrosc. 2025 Feb 5;326:125239. doi: 10.1016/j.saa.2024.125239. Epub 2024 Oct 2.
Surface-enhanced Raman scattering (SERS) spectroscopy is a highly specific and ultrasensitive analytical technique; thus, it is an ideal candidate for therapeutic drug monitoring. However, SERS measurements of drugs in a sample are inevitably affected by the environment. In this study, we synthesized ZrO nanoparticles (NPs) doped with the first group of elements (Li, Na, and K) in the main block and evaluated their SERS performance. The results showed that Li-ion doping could significantly enhance the SERS effect, and the degree of enhancement depended on the type and concentration of the doped ions. Compared with the highly stable ZrO, Li ion-doped ZrO (Li-ZrO) exhibited a significant increase in SERS activity. In particular, 1 % Li-ZrO NPs exhibited excellent SERS enhancement with an enhancement factor (EF) of 2.60 × 10, which was attributed to the decreased band gap and improved the charge transfer (CT) process after Li ion doping. The adsorption capacity of the Li-ZrO NPs for norfloxacin (NOR) molecules was gradually saturated with time. In addition, both acidic and alkaline conditions were unfavorable for NOR detection by the substrate. The SERS intensity exhibited a linear relationship within the NOR concentration range of 10-10 mol/L, and approximately 97.51 % of the active ingredients were detected, with a competitive detection limit of 10 mol/L. Furthermore, NOR detection is cost-effective and time-efficient, and the results of our study can aid in the research process and support practical applications. The proposed study provides a guidance for improving the SERS activity of semiconductors for sensing.
表面增强拉曼散射（SERS）光谱学是一种高度特异性和超灵敏的分析技术；因此，它是治疗药物监测的理想候选者。然而，样品中药物的 SERS 测量不可避免地受到环境的影响。在这项研究中，我们合成了掺杂第一主族元素（Li、Na 和 K）的 ZrO 纳米粒子（NPs），并评估了它们的 SERS 性能。结果表明，锂离子掺杂可以显著增强 SERS 效应，增强程度取决于掺杂离子的类型和浓度。与高度稳定的 ZrO 相比，Li 离子掺杂的 ZrO（Li-ZrO）表现出显著增强的 SERS 活性。特别是，1%Li-ZrO NPs 的 SERS 增强因子（EF）高达 2.60×10，这归因于 Li 离子掺杂后带隙减小和电荷转移（CT）过程的改善。Li-ZrO NPs 对诺氟沙星（NOR）分子的吸附容量随时间逐渐饱和。此外，酸性和碱性条件都不利于基底检测 NOR。SERS 强度在 NOR 浓度范围为 10-10 mol/L 内呈线性关系，检测到约 97.51%的有效成分，竞争检测限为 10 mol/L。此外，NOR 检测具有成本效益和时间效益，我们的研究结果可以为传感用半导体的 SERS 活性的提高提供指导。本研究为提高半导体的 SERS 活性提供了指导，为传感应用提供了支持。
