Beldick Stephanie R, Rockter Adam, Beck Allen D, Levin Alex V
Flaum Eye Institute, University of Rochester Medical Center, Rochester, New York.
Emory Eye Center, Emory University School of Medicine, Atlanta, Georgia.
Ophthalmol Glaucoma. 2025 Mar-Apr;8(2):175-180. doi: 10.1016/j.ogla.2024.10.001. Epub 2024 Oct 9.
To report on epidemiologic data from an international, centralized pediatric glaucoma database of 872 patients, focusing on genetic and clinically significant factors.
Database study utilizing retrospective analysis.
Eight hundred seventy-two children, both female and male, were included in the database. After accounting for database coding errors, data from 865 patients with pediatric glaucoma were analyzed. Number of eyes analyzed fluctuated for each variable.
The registry is an open access, no charge, Research Electronic Data Capture database. Participating clinical centers input data with local Institutional Review Board approval and subsequently have access for research purposes. We retrospectively reviewed 872 patients, comparing demographics, family history, country, disease presentation, and Childhood Glaucoma Research Network diagnoses. Analyses for each variable were conducted in SPSS Software v.28.0. Chi-square analyses were performed for nominal data, and ordinal and continuous data were analyzed using Mann-Whitney test, analysis of variance, or Kruskal-Wallis tests with multiple comparisons.
Childhood Glaucoma Research Network glaucoma type and markers of clinical severity by country (laterality, cup-to-disc ratio [CTD], corneal diameter, opacification, edema; visual acuity [VA], intraocular pressure, Haab striae, axial length).
Twenty clinical sites from 10 countries entered data. Centers in the USA, India, and Iran input the most data. In the USA, open-angle glaucoma following cataract surgery was most common, while in India and Iran it was primary congenital glaucoma neonatal onset. Bilateral disease was more frequent in India and Iran compared to the USA (X = 50.6, P < 0.001). Clinical measures of severity were typically worse in India compared to the USA. This included increased CTD (X = 24.0, P = 0.002), increased corneal diameter (X = 8.9, P = 0.01), presence of corneal opacification (X = 10.7, P = 0.001), presence of corneal edema (X = 11.7, P < 0.001), and worse VA (U = 873.5, P < 0.001). Intraocular pressure and presence of Haab striae were not associated with country (P > 0.05), while axial length was increased in the USA by an average of 1.04 mm (U = 5787, P = 0.002).
This registry has potential to advance our understanding of pediatric glaucoma. Differences in family history, disease presentation, and glaucoma type suggest unique country phenotypes. Registry expansion may allow for insight into best practices for pediatric glaucoma.
FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
报告来自一个国际集中式儿科青光眼数据库的872例患者的流行病学数据，重点关注遗传和具有临床意义的因素。
利用回顾性分析的数据库研究。
数据库纳入了872名儿童，包括男性和女性。在纠正数据库编码错误后，对865例儿科青光眼患者的数据进行了分析。每个变量分析的眼数有所波动。
该登记处是一个开放获取、免费的研究电子数据采集数据库。参与的临床中心在获得当地机构审查委员会批准后输入数据，随后可用于研究目的。我们回顾性分析了872例患者，比较了人口统计学、家族史、国家、疾病表现以及儿童青光眼研究网络的诊断。使用SPSS软件v.28.0对每个变量进行分析。对名义数据进行卡方分析，对有序和连续数据使用曼-惠特尼检验、方差分析或具有多重比较的克鲁斯卡尔-沃利斯检验进行分析。
儿童青光眼研究网络青光眼类型以及按国家划分的临床严重程度指标（双眼性、杯盘比[CTD]、角膜直径、混浊、水肿；视力[VA]、眼压、哈布条纹、眼轴长度）。
来自10个国家的20个临床站点输入了数据。美国、印度和伊朗的中心输入的数据最多。在美国，白内障手术后的开角型青光眼最为常见，而在印度和伊朗则是原发性先天性青光眼新生儿发病型。与美国相比，印度和伊朗的双眼疾病更为常见（X = 50.6，P < 0.001）。与美国相比，印度的临床严重程度指标通常更差。这包括CTD增加（X = 24.0，P = 0.002）、角膜直径增加（X = 8.9，P = 0.01）、角膜混浊（X = 10.7，P = 0.001）、角膜水肿（X = 11.7，P < 0.001）以及更差的VA（U = 873.5，P < 0.001）。眼压和哈布条纹的存在与国家无关（P > 0.05），而美国的眼轴长度平均增加了1.04 mm（U = 5787，P = 0.002）。
该登记处有潜力增进我们对儿科青光眼的了解。家族史、疾病表现和青光眼类型的差异表明存在独特的国家表型。扩大登记处可能有助于深入了解儿科青光眼的最佳治疗方法。
本文末尾的脚注和披露中可能会有专有或商业披露信息。
