Samuels Jason M, Patel Mayur B, Roumie Christianne L, Self Wesley, Funk Luke, Spann Matthew D, Niswender Kevin D
Section of Surgical Sciences, Division of General Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Department of Surgery, Veterans Administration Tennessee, Nashville, Tennessee.
Surg Obes Relat Dis. 2025 Feb;21(2):109-114. doi: 10.1016/j.soard.2024.08.041. Epub 2024 Sep 14.
Few studies have investigated the use of anti-obesity medications (AOMs) before bariatric surgery and how prior use impacts patients' goals and expectations for surgery.
This study investigated associations between patients' experiences with AOMs and weight loss expectations before bariatric surgery.
Single tertiary university hospital.
Patients were electronically surveyed with a 31-item questionnaire via email or the patient portal with a primary predictor variable of AOMs presurgery. Outcomes included degree of weight loss and weight regain and motivation for seeking surgery.
A total of 346 persons were invited to complete the survey; 112 surveys (32.4%) were completed, with 7 excluded because of not answering the AOM question. 73% reported AOM use. Among those who took AOMs before seeking bariatric surgery, average weight loss was 13 kg (SD 10) corresponding to a 4.4-kg/m decrease in BMI. Of past AOM recipients, 87% reported weight regain on stopping AOMs. Average weight regain was 18 kg (SD 13; 126% increase). Patients reported improved longevity and quality of life as motivation for seeking surgery, with AOM use history having no effect. Subjects reported an average weight loss goal of 65.8 kg (39% of baseline weight) from bariatric surgery.
AOMs were commonly used in those seeking bariatric surgery, but motivation for surgery did not differ by AOM use history. Motivations were most often related to goals for better overall health.
很少有研究调查减肥手术前使用抗肥胖药物（AOMs）的情况，以及先前的使用如何影响患者对手术的目标和期望。
本研究调查了减肥手术前患者使用AOMs的经历与体重减轻期望之间的关联。
单一的三级大学医院。
通过电子邮件或患者门户网站对患者进行电子问卷调查，问卷包含31个项目，主要预测变量为术前使用AOMs的情况。结果包括体重减轻程度、体重反弹情况以及寻求手术的动机。
共邀请346人完成调查；112份问卷（32.4%）被完成，其中7份因未回答AOM问题而被排除。73%的人报告使用过AOMs。在寻求减肥手术前服用AOMs的患者中，平均体重减轻13千克（标准差10），相当于体重指数（BMI）下降4.4千克/米²。在过去使用过AOMs的患者中，87%的人报告停止使用AOMs后体重反弹。平均体重反弹18千克（标准差13；增加126%）。患者报告改善寿命和生活质量是寻求手术的动机，AOM使用史对此没有影响。受试者报告减肥手术的平均体重减轻目标为65.8千克（占基线体重的39%）。
寻求减肥手术的患者中普遍使用AOMs，但手术动机不因AOM使用史而异。动机最常与改善整体健康的目标相关。
