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原发性开角型青光眼治疗中微侵袭性青光眼手术的种族差异:一项倾向匹配队列研究

Racial Disparities in Microinvasive Glaucoma Surgery for Management of Primary Open-Angle Glaucoma: A Propensity-Matched Cohort Study.

作者信息

Vasu Pranav, Hall Rigel P, Wagner Isabella V, Lentz P Connor, Abubaker Yazan, Shokair Aya, Boopathiraj Nithya, Qozat Ibrahim, Miller Darby D, Dorairaj Syril

机构信息

From the Department of Medicine, Creighton University School of Medicine (P.V., R.P.H.), Phoenix, Arizona.

Department of Ophthalmology, Mayo Clinic (I.V.W., P.C.L., Y.A., N.B., I.Q., D.D.M., S.D.), Jacksonville, Florida.

出版信息

Am J Ophthalmol. 2025 Mar;271:96-103. doi: 10.1016/j.ajo.2024.10.006. Epub 2024 Oct 10.

Abstract

PURPOSE

To evaluate racial and ethnic differences in the use of microinvasive glaucoma surgery (MIGS) for the management of mild-moderate primary open-angle glaucoma (POAG) in the United States.

DESIGN

Retrospective cohort study.

PARTICIPANTS

Patients with a diagnosis of mild or moderate POAG, as defined by Current Procedural Terminology (CPT) codes, were included. The experimental group comprised African American (AA) patients, and the control group consisted of patients without an AA designation in the TriNetX database.

METHODS

Propensity scoring was used to match cohorts for age at diagnosis, Charlson Comorbidity Index, sex, nicotine dependence, glaucoma medications, family history of POAG, body mass index, and weight. Outcome was incidence of MIGS over 1 year of follow-up. Odds ratios were calculated between cohorts.

MAIN OUTCOME MEASURE

Incidence of MIGS over 1 year of follow-up post-POAG diagnosis.

RESULTS

A total of 63,418 POAG patients were included (50% AA, 50% non-AA). AA patients were found to undergo MIGS at a significantly lower rate (1,268 of 31,709) compared with non-AA patients (1,508 of 31,709) (odds ratio 0.834, 95% CI 0.773-0.900).

CONCLUSION

Although POAG is understood to be more prevalent among African Americans, these patients display lower use of MIGS, suggesting a possible nationwide racial disparity in the management of POAG.

摘要

目的

评估美国在使用微创青光眼手术(MIGS)治疗轻度至中度原发性开角型青光眼(POAG)方面的种族和民族差异。

设计

回顾性队列研究。

参与者

纳入根据现行程序术语(CPT)代码定义为轻度或中度POAG的患者。实验组包括非裔美国(AA)患者,对照组由TriNetX数据库中无AA标识的患者组成。

方法

采用倾向评分法对队列进行匹配,匹配因素包括诊断时的年龄、查尔森合并症指数、性别、尼古丁依赖、青光眼药物治疗、POAG家族史、体重指数和体重。观察指标为随访1年期间MIGS的发生率。计算队列之间的比值比。

主要观察指标

POAG诊断后随访1年期间MIGS的发生率。

结果

共纳入63418例POAG患者(50%为AA患者,50%为非AA患者)。发现AA患者接受MIGS的比例(31709例中的1268例)显著低于非AA患者(31709例中的1508例)(比值比0.834,95%可信区间0.773 - 0.900)。

结论

尽管POAG被认为在非裔美国人中更为普遍,但这些患者接受MIGS的比例较低,这表明在POAG的治疗方面可能存在全国性的种族差异。

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