“透明老鼠”：使用食物染料进行深层组织活体成像。
'Transparent mice': deep-tissue live imaging using food dyes.
机构信息
Department of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO, USA.
出版信息
Commun Biol. 2024 Oct 11;7(1):1307. doi: 10.1038/s42003-024-07012-9.
Abstract
Light scattering, resulting from refractive index mismatch, is the primary factor limiting imaging depth in biological tissue. In a study recently published in , Ou et al. took an unconventional approach and employed highly absorbing molecules, such as food dye tartrazine, to increase the refractive index of water in the near-infrared wavelength range, which rendered tissue transparent in live mice.
摘要
光散射是由折射率失配引起的，是限制生物组织成像深度的主要因素。在最近发表在 的一项研究中，Ou 等人采取了一种非传统的方法，使用高吸收分子，如食用色素柠檬黄，来增加近红外波长范围内水的折射率，从而使活体小鼠的组织变得透明。
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