Brown D R, Callahan B G, Cleaves M A, Schatz R A
Toxicol Ind Health. 1985 Sep;1(1):81-98. doi: 10.1177/074823378500100109.
The effects of exposures to low levels of heavy metals is a complex and serious problem. Thallium is a metal which produces behavioral sequelae in human poisoning and is potentially hazardous with low level exposures. A test battery is presented which utilizes biochemical and behavioral testing to assess the effects of low levels of thallium on central nervous system chemistry and function in rats. The doses of thallium used (4 and 8 mg/kg) produced no overt signs of behavioral toxicity but did produce dose-related increases in lipid peroxidation and activation of the lysosomal enzyme beta-galactosidase in selected brain regions. At these dose levels, thallium also selectively altered the patterns of behavior. The study suggests that the target regions of thallium in the brain include the cortex, the cerebellum and the brainstem. The dose-response relationships, found for certain pairs of behavioral acts, were correlated with biochemical changes in one or more brain regions.
接触低水平重金属的影响是一个复杂而严重的问题。铊是一种在人体中毒时会产生行为后遗症的金属，低水平接触也可能具有危险性。本文介绍了一套测试方法，利用生化和行为测试来评估低水平铊对大鼠中枢神经系统化学物质和功能的影响。所用的铊剂量（4毫克/千克和8毫克/千克）未产生明显的行为毒性迹象，但确实在选定的脑区产生了与剂量相关的脂质过氧化增加以及溶酶体酶β-半乳糖苷酶的激活。在这些剂量水平下，铊还选择性地改变了行为模式。该研究表明，铊在大脑中的目标区域包括皮层、小脑和脑干。在某些行为对中发现的剂量反应关系与一个或多个脑区的生化变化相关。
