Norman Sarah J, Carney Ayzia C, Algarin Fernanda, Witt Brittany, Witzel Ivette M, Rodriguez Paula M, Mohyeldin Moiud
Internal Medicine, American University of the Caribbean School of Medicine, Cupecoy, SXM.
Emergency Medicine, American University of the Caribbean School of Medicine, Cupecoy, SXM.
Cureus. 2024 Sep 11;16(9):e69182. doi: 10.7759/cureus.69182. eCollection 2024 Sep.
Thyroid disorders are common in medicine, while bipolar disorders (BDs), though less frequent, are significant due to global prevalence, the economic burden on healthcare systems and long-term health implications, and the effects of psychiatric illness on quality of life. Clinical research has suggested thyroid hormone imbalances can cause psychiatric symptoms similar to the clinical features observed in BDs. Despite increased attention in this area of study, much remains unknown regarding how thyroid issues contribute to the development of BDs. This review explores the complex link between thyroid disorders and BDs, focusing on neurochemical dynamics, changes in the hypothalamic-pituitary-thyroid (HPT) axis, and genetic factors. Furthermore, this literature review examines the importance of understanding these factors in linking both conditions and emphasizes the necessity for therapies targeting their shared underlying mechanisms.
甲状腺疾病在医学中很常见，而双相情感障碍（BDs）虽然发病率较低，但由于其全球患病率、对医疗保健系统的经济负担、长期健康影响以及精神疾病对生活质量的影响，也具有重要意义。临床研究表明，甲状腺激素失衡可导致与BDs中观察到的临床特征相似的精神症状。尽管该研究领域受到了越来越多的关注，但关于甲状腺问题如何导致BDs的发展仍有许多未知之处。本综述探讨了甲状腺疾病与BDs之间的复杂联系，重点关注神经化学动力学、下丘脑-垂体-甲状腺（HPT）轴的变化以及遗传因素。此外，这篇文献综述考察了理解这些因素在关联这两种疾病中的重要性，并强调了针对其共同潜在机制进行治疗的必要性。
