Zhang Yan, Shi Xinyu, Shen Yifan, Dong Xiulin, He Ruiqing, Chen Guo, Zhang Yan, Tan Honghong, Zhang Kun
Central Laboratory and Department of Medical Ultrasound, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China Chengdu China.
Department of VIP Clinic General Division, Shanghai East Hospital, School of Medicine Tongji University Shanghai China.
MedComm (2020). 2024 Oct 10;5(10):e755. doi: 10.1002/mco2.755. eCollection 2024 Oct.
Oncolytic viruses (OVs) have emerged as a powerful tool in cancer therapy. Characterized with the unique abilities to selectively target and lyse tumor cells, OVs can expedite the induction of cell death, thereby facilitating effective tumor eradication. Nanoengineering-derived OVs overcome traditional OV therapy limitations by enhancing the stability of viral circulation, and tumor targeting, promising improved clinical safety and efficacy and so on. This review provides a comprehensive analysis of the multifaceted mechanisms through which engineered OVs can suppress tumor progression. It initiates with a concise delineation on the fundamental attributes of existing OVs, followed by the exploration of their mechanisms of the antitumor response. Amid rapid advancements in nanomedicine, this review presents an extensive overview of the latest developments in the synergy between nanomaterials, nanotechnologies, and OVs, highlighting the unique characteristics and properties of the nanomaterials employed and their potential to spur innovation in novel virus design. Additionally, it delves into the current challenges in this emerging field and proposes strategies to overcome these obstacles, aiming to spur innovation in the design and application of next-generation OVs.
溶瘤病毒已成为癌症治疗中的一种强大工具。溶瘤病毒具有选择性靶向和裂解肿瘤细胞的独特能力，能够加速细胞死亡的诱导，从而有助于有效根除肿瘤。纳米工程衍生的溶瘤病毒通过增强病毒循环的稳定性和肿瘤靶向性克服了传统溶瘤病毒疗法的局限性，有望提高临床安全性和疗效等。本综述全面分析了工程化溶瘤病毒抑制肿瘤进展的多方面机制。首先简要描述了现有溶瘤病毒的基本特性，随后探讨了它们的抗肿瘤反应机制。在纳米医学快速发展的背景下，本综述广泛概述了纳米材料、纳米技术与溶瘤病毒协同作用的最新进展，突出了所采用纳米材料的独特特征和性质及其在新型病毒设计中激发创新的潜力。此外，它深入探讨了这一新兴领域当前面临的挑战，并提出了克服这些障碍的策略，旨在推动下一代溶瘤病毒设计和应用的创新。
