CIRI, Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, Univ Lyon, 69007 Lyon, France.
Université de Lyon, VeAgro Sup, 69280 Marcy l'Etoile, France.
Microb Genom. 2024 Oct;10(10). doi: 10.1099/mgen.0.001292.
is a globally distributed opportunistic pathogen in human health settings, including in intensive care units (ICUs). We investigated the contamination of a French small animal ICU with . We discovered repeated animal contamination by , and phylogenetic analysis traced contamination back to a potential foreign animal origin. Genomic analysis combined with antibiotic susceptibility testing revealed heteroresistance to penicillin and aminoglycoside mediated by insertion sequence dynamics and also suggest a potential cross-resistance to human-restricted piperacillin-tazobactam combination. The isolates of the animal ICU belong to the International Clone 2 commonly found in human health settings. Our results suggest a high adaptation of this lineage to healthcare settings and provide questions on the requirements for genetic determinants enabling adaptation to host and abiotic conditions.
是一种在人类健康环境中分布广泛的机会性病原体，包括在重症监护病房（ICU）中。我们调查了法国一家小动物 ICU 中的污染情况。我们发现 反复污染动物，并通过系统发育分析追溯到潜在的外来动物来源。基因组分析结合抗生素药敏试验显示，插入序列动力学介导的青霉素和氨基糖苷类药物异质性耐药，也提示对人类受限的哌拉西林-他唑巴坦联合用药有潜在的交叉耐药性。动物 ICU 的 分离株属于国际克隆 2 型，通常在人类健康环境中发现。我们的结果表明，这种谱系高度适应医疗保健环境，并提出了有关遗传决定因素要求的问题，这些决定因素使它们能够适应宿主和非生物条件。
