Liu Xiaojin, Zhang Yuze, Weng Yihe, Zhong Miao, Wang Lijuan, Gao Zhenni, Hu Huiqing, Zhang Yuhu, Huang Biao, Huang Ruiwang
Center for Educational Science and Technology, Beijing Normal University, Zhuhai 519087, China; School of Psychology, Center for Studies of Psychological Application, Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou 510631, China; Key Laboratory of Brain, Cognition and Education Sciences (South China Normal University), Ministry of Education, Guangzhou 510631, China.
Department of Radiology, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Guangzhou 510080, China.
Prog Neuropsychopharmacol Biol Psychiatry. 2025 Jan 10;136:111169. doi: 10.1016/j.pnpbp.2024.111169. Epub 2024 Oct 12.
Levodopa (L-dopa) therapy is the most effective pharmacological treatment for motor symptoms of Parkinson's disease (PD). However, its effect on brain functional network dynamics is still unclear. Here, we recruited 26 PD patients and 24 healthy controls, and acquired their resting-state functional MRI data before (PD-OFF) and after (PD-ON) receiving 400 mg L-dopa. Using the independent component analysis and the sliding-window approach, we estimated the dynamic functional connectivity (dFC) and examined the effect of L-dopa on the temporal properties of dFC states, the variability of dFC and functional network topological organization. We found that PD-ON showed decreased mean dwell time in sparsely connected State 2 than PD-OFF, the transformation of the dFC state is more frequent and the variability of dFC was decreased within the auditory network and sensorimotor network in PD-ON. Our findings provide new insights to understand the dynamic neural activity induced by L-dopa therapy in PD patients.
左旋多巴（L-多巴）疗法是治疗帕金森病（PD）运动症状最有效的药物治疗方法。然而，其对脑功能网络动力学的影响仍不清楚。在此，我们招募了26名PD患者和24名健康对照者，并在接受400毫克L-多巴之前（关期PD）和之后（开期PD）获取了他们的静息态功能磁共振成像数据。使用独立成分分析和滑动窗口方法，我们估计了动态功能连接性（dFC），并研究了L-多巴对dFC状态的时间特性、dFC的变异性和功能网络拓扑组织的影响。我们发现，与关期PD相比，开期PD在稀疏连接的状态2中的平均停留时间减少，dFC状态的转变更频繁，并且在开期PD的听觉网络和感觉运动网络中dFC的变异性降低。我们的研究结果为理解L-多巴疗法在PD患者中诱导的动态神经活动提供了新的见解。
