基于 A-D-A 结构的光伏分子光热治疗剂用于近红外荧光成像引导的肿瘤协同光动力和光热治疗。
Photovoltaic Molecule-Based Phototheranostics With A-D-A Structure for Near-Infrared Fluorescence Imaging-Guided Synergetic Photodynamic and Photothermal Therapy of Tumors.
机构信息
Department of Infectious Diseases, Hunan Provincial People's Hospital, First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China.
Department of Rheumatology and Immunology, Hunan Provincial People's Hospital, First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China.
出版信息
Luminescence. 2024 Oct;39(10):e4930. doi: 10.1002/bio.4930.
Phototheranostics with near-infrared fluorescence and reactive oxygen species generation ability and high photothermal conversion efficiency (PCE) plays a significant role in fluorescence imaging-guided synergetic photodynamic and photothermal therapy of tumors. Here, a star molecule in organic photovoltaic materials, NCBDT-4C with an A-D-A conjugated structure, was assembled with DSPE-PEG-NH to prepare water dispersive nanoparticles (NPs). The prepared NCBDT-4Cl NPs exhibited a maximum NIR absorption peak at 764 nm and a maximum fluorescence peak at 798 nm. These NPs could generate superoxide anion, singlet oxygen (O), and heat under 808 nm laser irradiation. The O generation quantum yield and PCE of the NPs were 37.5% and 53.6%, respectively. The combination of photodynamic and photothermal therapy of cancer was demonstrated in vitro and in vivo. This work presents the advanced application of organic photovoltaic materials in cancer phototherapy.
具有近红外荧光和活性氧生成能力以及高光热转换效率（PCE）的光热治疗在荧光成像引导的肿瘤协同光动力和光热治疗中起着重要作用。在这里，将具有 A-D-A 共轭结构的有机光伏材料中的星型分子 NCBDT-4C 与 DSPE-PEG-NH 组装，制备水分散性纳米粒子（NPs）。所制备的 NCBDT-4Cl NPs 在 764nm 处表现出最大的近红外吸收峰，在 798nm 处表现出最大的荧光峰。这些 NPs 在 808nm 激光照射下可以产生超氧阴离子、单线态氧（O）和热量。NPs 的 O 生成量子产率和 PCE 分别为 37.5%和 53.6%。在体外和体内证明了癌症的光动力和光热联合治疗。这项工作展示了有机光伏材料在癌症光疗中的高级应用。
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