Children and Reproductive Health, Institute of Women, Jinan, Shandong, 250012, China.
School of Basic Medical Sciences, Shandong University, Jinan, Shandong, 250012, China.
BMC Med. 2024 Oct 14;22(1):462. doi: 10.1186/s12916-024-03654-y.
While most research has focused on the association between intracytoplasmic sperm injection (ICSI) and neurodevelopmental disorders in children, relatively little attention has been given to its metabolic effects. Previous studies have reported that low serum lipid levels are associated with mental health problems. Our objective was to analyze the impact of ICSI on metabolic alterations compared to their in vitro fertilization (IVF) counterparts in male offspring, as well as its interaction with paternal overweight/obesity.
We recruited families between January 2006 and December 2017 at the Center for Reproductive Medicine, Shandong University, China. Prospective data of offspring were obtained for body mass index (BMI), blood pressure, glucose, and lipid profile in their 0-11 years old. Linear mixed models were utilized to compute the mean difference and 95% confidence intervals (CI).
A total of 14,196 offspring visits were identified. In offspring aged 4-11 years, ICSI-conceived offspring exhibited significantly lower fasting glucose z-scores, total cholesterol z-scores, and low-density lipoprotein cholesterol (LDL-C) z-scores compared with their IVF counterparts (fasting glucose z-score: adjusted mean difference: - 0.13, 95% CI: - 0.23 to - 0.03; total cholesterol z-score: adjusted mean difference: - 0.13, 95% CI: - 0.23 to - 0.02; LDL-C z-score: adjusted mean difference: - 0.12, 95% CI: - 0.22 to - 0.01). Paternal overweight/obesity significantly influenced the relationship between ICSI and metabolic changes in offspring. In offspring born from fathers with overweight/obesity, ICSI-conceived offspring displayed significantly lower fasting glucose and total cholesterol z-scores than their IVF controls (fasting glucose z-score: adjusted mean difference: - 0.20, 95% CI: - 0.32 to - 0.08; total cholesterol z-score: adjusted mean difference: - 0.15, 95% CI: - 0.27 to - 0.02). In offspring born to fathers with normal weight, ICSI-conceived offspring showed significantly lower systolic blood pressure z-scores compared to those conceived via the IVF procedures (adjusted mean difference: - 0.21, 95% CI: - 0.37 to - 0.05).
The findings of this study suggested that ICSI was associated with altered glucose and lipid profiles compared to their IVF controls, characterized by lower fasting glucose z-scores, total cholesterol z-scores, and LDL-C z-scores. Encouraging fathers to reduce their body weight could potentially improve the metabolic health of their ICSI-conceived children.
虽然大多数研究都集中在胞浆内精子注射（ICSI）与儿童神经发育障碍之间的关系上，但相对较少关注其代谢影响。先前的研究报告称，血清脂质水平低与心理健康问题有关。我们的目的是分析 ICSI 对代谢改变的影响，与他们的体外受精（IVF）的男性后代相比，以及其与父亲超重/肥胖的相互作用。
我们于 2006 年 1 月至 2017 年 12 月在山东大学生殖医学中心招募了家庭。前瞻性数据的后代获得了体重指数（BMI）、血压、血糖和血脂谱在他们的 0-11 岁。线性混合模型用于计算均值差和 95%置信区间（CI）。
共确定了 14196 次后代访问。在 4-11 岁的后代中，ICSI 受孕的后代与 IVF 对照组相比，空腹血糖 z 评分、总胆固醇 z 评分和低密度脂蛋白胆固醇（LDL-C）z 评分显著降低（空腹血糖 z 评分：调整平均差异：-0.13，95%CI：-0.23 至-0.03；总胆固醇 z 评分：调整平均差异：-0.13，95%CI：-0.23 至-0.02；LDL-C z 评分：调整平均差异：-0.12，95%CI：-0.22 至-0.01）。父亲超重/肥胖显著影响 ICSI 与后代代谢变化之间的关系。在父亲超重/肥胖的后代中，ICSI 受孕的后代与 IVF 对照组相比，空腹血糖和总胆固醇 z 评分明显降低（空腹血糖 z 评分：调整平均差异：-0.20，95%CI：-0.32 至-0.08；总胆固醇 z 评分：调整平均差异：-0.15，95%CI：-0.27 至-0.02）。在父亲体重正常的后代中，ICSI 受孕的后代与 IVF 组相比，收缩压 z 评分明显降低（调整平均差异：-0.21，95%CI：-0.37 至-0.05）。
本研究结果表明，与 IVF 对照组相比，ICSI 与葡萄糖和脂质谱的改变有关，表现为空腹血糖 z 评分、总胆固醇 z 评分和 LDL-C z 评分较低。鼓励父亲减轻体重可能会改善 ICSI 受孕儿童的代谢健康。
