Mak Jonathan K L, Tan Kathryn Choon Beng, Wong Janus Siu Him, Chung Martin Man Ho, Cheung Ching-Lung
Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong SAR, China.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Osteoporos Sarcopenia. 2024 Sep;10(3):114-118. doi: 10.1016/j.afos.2024.08.002. Epub 2024 Sep 11.
This study aimed to investigate the relationships of foot and leg symptoms, structure, and function with functional limitations and osteoarthritis (OA).
We included 1253 participants (mean age 58.1 years) from the Hong Kong Osteoporosis Study who completed an examination on foot posture, function, pain, and presence of deformities such as hallux valgus and varus knee. Using logistic regression, we estimated cross-sectional associations of each foot and knee problem with functional outcomes (slow walking speed, self-reported falls, and functional limitations) and OA. Through linkage to electronic health records, we further examined their associations with incident OA over 8 years using Cox models. All models were adjusted for age, sex, and body mass index.
The prevalence of hallux valgus, foot pain, and varus knee were 33.1%, 35.1%, and 25.8%, respectively. Planus foot posture was associated with varus knee, and pronated foot function was associated with hallux valgus. Of the assessed foot problems, only foot pain showed significant associations with functional outcomes, including functional limitations and recurrent falls. Foot pain was also associated with prevalent OA at baseline but not incident OA. Meanwhile, we observed a 3-times increased risk of incident OA associated with varus knee (95% CI = 1.48-6.10), and this association was particularly seen in older adults, women, and obese individuals.
In community-dwelling Chinese adults, foot pain, but not the reported foot deformities, is associated with functional limitations and falls, while varus knee is associated with incident OA.
本研究旨在调查足部和腿部症状、结构及功能与功能受限及骨关节炎（OA）之间的关系。
我们纳入了香港骨质疏松症研究中的1253名参与者（平均年龄58.1岁），他们完成了足部姿势、功能、疼痛以及诸如拇外翻和膝内翻等畸形情况的检查。使用逻辑回归，我们估计了每个足部和膝部问题与功能结局（步行速度缓慢、自我报告的跌倒及功能受限）和OA之间的横断面关联。通过与电子健康记录相链接，我们使用Cox模型进一步研究了它们在8年期间与新发OA的关联。所有模型均对年龄、性别和体重指数进行了校正。
拇外翻、足部疼痛和膝内翻的患病率分别为33.1%、35.1%和25.8%。扁平足姿势与膝内翻相关，旋前足功能与拇外翻相关。在所评估的足部问题中，只有足部疼痛与功能结局显著相关，包括功能受限和反复跌倒。足部疼痛在基线时也与现患OA相关，但与新发OA无关。同时，我们观察到膝内翻与新发OA的风险增加3倍相关（95%CI = 1.48 - 6.10），这种关联在老年人、女性和肥胖个体中尤为明显。
在社区居住的中国成年人中，足部疼痛而非所报告的足部畸形与功能受限和跌倒相关，而膝内翻与新发OA相关。
