Department of Endocrinology and Metabolism, Chungnam National University Hospital, Daejeon, Republic of Korea.
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
Front Endocrinol (Lausanne). 2024 Sep 30;15:1416326. doi: 10.3389/fendo.2024.1416326. eCollection 2024.
Uteroglobin is a multifunctional protein with anti-inflammatory properties. Studies have revealed the importance of inflammation in type 2 diabetes mellitus (T2D) pathogenesis. Here, we investigated the relationship between uteroglobin and T2D.
We performed diagnostic tests for diabetes in subjects who had not been diagnosed with or treated for T2D. We established three groups, containing those with normal glucose tolerance (NGT), prediabetes and T2D, consisting of 80 people each, and compared their uteroglobin levels. In addition, 28 patients newly diagnosed with T2D were treated with metformin for 12 weeks, and 63 patients newly diagnosed with dyslipidaemia during the treatment for T2D were treated with statin for 12 weeks.
This study showed that uteroglobin levels were significantly lower in prediabetes and T2D groups than in the NGT group. Uteroglobin levels were not significantly correlated with other metabolic parameters, except BMI, HOMA-β and eGFR. In the group treated with metformin or statin, uteroglobin levels increased after treatment compared to before treatment.
Uteroglobin is a sensitive factor that was decreased even in prediabetes and increased upon treatment with drugs with anti-inflammatory effects. Uteroglobin is a potential early biomarker that reflects a chronic inflammatory condition in T2D.
尿调节蛋白是一种具有抗炎特性的多功能蛋白。研究表明炎症在 2 型糖尿病（T2D）发病机制中起重要作用。在这里，我们研究了尿调节蛋白与 T2D 的关系。
我们对未经诊断或治疗 T2D 的受试者进行了糖尿病诊断测试。我们建立了三个组，每组 80 人，分别为糖耐量正常（NGT）、糖尿病前期和 T2D，比较了他们的尿调节蛋白水平。此外，28 例新诊断为 T2D 的患者接受二甲双胍治疗 12 周，63 例新诊断为血脂异常的 T2D 患者接受他汀类药物治疗 12 周。
本研究表明，糖尿病前期和 T2D 组的尿调节蛋白水平明显低于 NGT 组。尿调节蛋白水平与其他代谢参数无显著相关性，除 BMI、HOMA-β 和 eGFR 外。在接受二甲双胍或他汀类药物治疗的组中，治疗后尿调节蛋白水平较治疗前升高。
尿调节蛋白是一种敏感的因素，即使在糖尿病前期也会降低，而具有抗炎作用的药物治疗后会升高。尿调节蛋白是反映 T2D 慢性炎症状态的潜在早期生物标志物。
