Wang B S, Lumanglas A L, Durr F E
Cancer Res. 1986 Feb;46(2):503-6.
Macrophages from mice treated with a novel antineoplastic agent, bisantrene, were shown previously to be highly active in inhibiting the proliferation of tumor cells in culture. These activated cells have now been found to protect mice from dying of progressive tumors when injected into animals. The effect was observed not only in a Winn-type tumor cell neutralization assay but also in a setting of therapeutic intervention. Multiple treatments with bisantrene-activated cells seemed more effective than a single treatment. Macrophages appeared to be the major effectors in this system, since treatment with carrageenan abolished the protective effect. Thus, present findings suggest that in addition to a direct cytotoxic effect of bisantrene, the activation of macrophages may contribute to the overall antitumor activity of the drug.
先前已表明，用新型抗肿瘤药物双胺苯吖啶处理过的小鼠巨噬细胞在抑制培养中的肿瘤细胞增殖方面具有高度活性。现已发现，将这些活化细胞注射到动物体内时，可保护小鼠免于死于进行性肿瘤。不仅在温氏肿瘤细胞中和试验中观察到了这种效果，而且在治疗干预的情况下也观察到了这种效果。用双胺苯吖啶活化细胞进行多次治疗似乎比单次治疗更有效。巨噬细胞似乎是该系统中的主要效应细胞，因为用角叉菜胶处理可消除这种保护作用。因此，目前的研究结果表明，除了双胺苯吖啶的直接细胞毒性作用外，巨噬细胞的活化可能有助于该药物的整体抗肿瘤活性。
