Department of Psychiatry, The Third People's Hospital of Fuyang, Fuyang, 236015, Anhui, China.
Department of Psychiatry, Fuyang Mental Health Center, Fuyang, 236015, China.
Sci Rep. 2024 Oct 15;14(1):24112. doi: 10.1038/s41598-024-76183-6.
Depressive disorder is a significant public health problem worldwide, which adversely affects children and adolescents' health. Impaired fasting blood glucose (IFG) is more common in depressive disorder, which becomes a clinical problem that needs to be focused on. The study purposed to determine the prevalence and related factors of IFG in Chinese children and adolescents with depressive disorder and the relationship between triglyceride and high-density lipoprotein cholesterol (TG/HDL-C) ratio and IFG. This research encompassed 756 individuals aged 8 to 18 with major depressive disorders, all diagnosed under DSM-5 criteria at the Third People's Hospital of Fuyang from January 2020 to December 2021. We detected fasting blood glucose (FBG) and lipid levels and assessed the suicidal behaviors and depressive symptoms severity of each participant. The sociodemographic and included study variables were collected and analyzed. Our study employed multiple logistic regression to discern independent factors affecting IFG in conjunction with depressive disorders among children and adolescents. The prevalence of IFG was 6.5% (49/756). IFG was positively correlated with FBG, BMI, TG, TG/HDL-C, and was negatively correlated with gender and the type of antidepressant drug taken. Binary logistic analysis showed that male (OR = 2.57, 95% CI: 1.43-4.63, P = 0.002) and higher levels of TG (OR = 1.63, 95% CI: 1.11-2.38, P = 0.013) were independently associated with IFG in children and adolescents with depressive disorder. The incidence of IFG in children and adolescents with depressive disorder was high and was positively related to the TG/HDL-C ratio. The evaluation and management of IFG in pediatric depression should extend beyond pharmacological interventions. Comprehensive strategies in both assessment and management of IFG are essential to address this condition effectively in young patients facing depressive disorders.
抑郁障碍是一个全球性的重大公共卫生问题，它对儿童和青少年的健康产生不利影响。空腹血糖受损（IFG）在抑郁障碍中更为常见，这成为一个需要关注的临床问题。本研究旨在确定中国儿童和青少年抑郁障碍患者 IFG 的患病率及相关因素，以及甘油三酯与高密度脂蛋白胆固醇（TG/HDL-C）比值与 IFG 的关系。本研究纳入了 2020 年 1 月至 2021 年 12 月在杭州市第三人民医院根据 DSM-5 标准诊断为单相重性抑郁障碍的 756 例 8 至 18 岁的个体。我们检测了空腹血糖（FBG）和血脂水平，并评估了每位参与者的自杀行为和抑郁症状严重程度。收集并分析了社会人口学和包括的研究变量。我们采用多因素 logistic 回归分析，以确定与儿童和青少年抑郁障碍相关的 IFG 的独立影响因素。IFG 的患病率为 6.5%（49/756）。IFG 与 FBG、BMI、TG、TG/HDL-C 呈正相关，与性别和服用的抗抑郁药类型呈负相关。二元逻辑分析显示，男性（OR=2.57，95%CI：1.43-4.63，P=0.002）和较高水平的 TG（OR=1.63，95%CI：1.11-2.38，P=0.013）与儿童和青少年抑郁障碍患者 IFG 独立相关。抑郁障碍儿童和青少年 IFG 的发生率较高，与 TG/HDL-C 比值呈正相关。儿科抑郁患儿 IFG 的评估和管理不应仅限于药物干预。在评估和管理 IFG 方面采取全面的策略对于有效治疗患有抑郁障碍的年轻患者至关重要。
