Jöhr Jane, Alioth Aurea, Catalano Chiuvé Sabina, Nazeeruddin Sameer, Belouaer Amani, Daniel Roy Thomas, Momjian Shahan, Diserens Karin, Bally Julien F
Service of Neurology, Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), 1011 Lausanne, Switzerland.
Service of Neurology, Department of Clinical Neurosciences, Geneva University Hospital, 1211 Geneva, Switzerland.
J Clin Med. 2024 Sep 27;13(19):5752. doi: 10.3390/jcm13195752.
This study reports two cases of Global Rostral Midbrain Syndrome (GRMS) and corpus callosum infarction in the context of shunt overdrainage caused by obstructive hydrocephalus due to aqueductal stenosis. We detail how thorough clinical evaluation and appropriate investigation helped avoid a coma misdiagnosis and describe the excellent response to pharmacological treatment and successful neurorehabilitation in both cases. We analyze the cognitive profile of patients with GRMS, a rare condition that mimics disorders such as coma and progressive supranuclear palsy at various stages. In conscious cases, GRMS typically presents with parkinsonian syndrome, Parinaud syndrome, and cognitive issues. The awareness of this rare complication of shunt overdrainage facilitates more accurate diagnosis and better management.
本研究报告了两例全球 Rostral 中脑综合征（GRMS）及胼胝体梗死病例，其发生于导水管狭窄导致梗阻性脑积水引起的分流过度引流情况下。我们详细阐述了全面的临床评估和恰当的检查如何有助于避免昏迷误诊，并描述了两例患者对药物治疗的良好反应及成功的神经康复情况。我们分析了 GRMS 患者的认知特征，GRMS 是一种罕见病症，在不同阶段类似昏迷和进行性核上性麻痹等疾病。在清醒病例中，GRMS 通常表现为帕金森综合征、Parinaud 综合征和认知问题。认识到这种分流过度引流的罕见并发症有助于更准确的诊断和更好的管理。
